Results 41 to 50 of about 373,653 (310)

Recent Advances in Optical DNA Biosensors Technology

CHIMIA, 2005
Recent advances in nucleic acids-based biosensors have led to the development of DNA biosensors for DNA hybridisation detection and for nucleic acid–ligand binding studies.
Bambang Kuswandi, Sara Tombelli, Giovanna Marazza, Marco Mascini   +3 more
doaj   +1 more source

X-ray Crystallographic Characterization of the Co(II)-substituted Tris-bound Form of the Aminopeptidase from \u3cem\u3eAeromonas proteolytica\u3c/em\u3e [PDF]

, 2007
The X-ray crystal structure of the Co(II)-loaded form of the aminopeptidase from Aeromonas proteolytica ([CoCo(AAP)]) was solved to 2.2 Å resolution. [CoCo(AAP)] folds into an α/β globular domain with a twisted β-sheet hydrophobic core sandwiched between
Bennett, Brian, Holz, Richard C., Moulin, Aaron, Munih, Petra, Petsko, Gregory A., Ringe, Dagmar, Stamper, Carin   +6 more
core   +1 more source

Allosteric Activation of the Par-6 PDZ Via a Partial Unfolding Transition [PDF]

, 2013
Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding, or allosteric control.
Kovrigin, Evgeni L., Peterson, Francis C., Volkman, Brian F., Whitney, Dustin S.   +3 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

4-[(E)-2-(1-Pyrenyl)Vinyl]Pyridine Complexes: How to Modulate the Toxicity of Heavy Metal Ions to Target Microbial Infections

Molecules
Pyrene derivatives are regularly proposed for use in biochemistry as dyes due to their photochemical characteristics. Their antibacterial properties are, however, much less well understood. New complexes based on 4-[(E)-2-(1-pyrenyl)vinyl]pyridine (PyPe)
Justine V. Schwarte, Aurélien Crochet, Katharina M. Fromm   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Theoretical Evaluation of Novel Thermolysin Inhibitors from Bacillus thermoproteolyticus. Possible Antibacterial Agents

Molecules, 2021
The search for new antibacterial agents that could decrease bacterial resistance is a subject in continuous development. Gram-negative and Gram-positive bacteria possess a group of metalloproteins belonging to the MEROPS peptidase (M4) family, which is ...
Emilio Lamazares, Desmond MacLeod-Carey, Fernando P. Miranda, Karel Mena-Ulecia   +3 more
doaj   +1 more source

Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain. A study using electrospray ionization mass spectrometry and fluorescence binding studies [PDF]

, 2002
Advances in understanding how GroEL binds to non-native proteins are reported. Conformational flexibility in the GroEL apical domain, which could account for the variety of substrates that GroEL binds, is illustrated by comparison of several independent ...
Adams, Boisvert, Braig, Braig, Brinker, Brocchierei, Brunger, Brunger, Buckle, Bukau, Chatellier, Chatellier, Chatellier, Chen, Collaborative Computational Project, N., Coyle, Dessauer, Ewalt, Feltham, Fenton, Ferrige, Grallert, Hartl, Hartl, HayerHartl, Hemmingsen, Hlodan, Houry, Hunt, Hutchinson, Jancarik, Jones, Jones, Kobayashi, Konermann, Kraunsoe, Kusmierczyk, Landry, Landry, Leslie, Loo, Ma, Murshudov, Navaza, Pace, Pflugrath, Ploegman, Raftery, Ranson, Robinson, Romano, Roseman, Rye, Sigler, Smith, Smote, Tanaka, Wang, Weber, Weber, Weissman, Xu, Zahn   +62 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Opposite Functions of CD30 Ligand Isoforms

Current Issues in Molecular Biology
TNFSF8/CD30 ligand is a TNF superfamily member expressed on several major immune cell types, including activated monocytes, B, and T cells. The signaling of CD30 ligand through its cognate CD30 receptor has been shown to have effects on cell ...
Ignat Printsev, Elyas Alalli, Janine Bilsborough   +2 more
doaj   +1 more source