Results 61 to 70 of about 373,653 (310)
Spectroscopic and Computational Studies of Reversible O\u3csub\u3e2\u3c/sub\u3e Binding by a Cobalt Complex of Relevance to Cysteine Dioxygenase [PDF]
, 2017 The substitution of non-native metal ions into metalloenzyme active sites is a common strategy for gaining insights into enzymatic structure and function.
Fiedler, Adam T. +2 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Use of a distant reporter group as evidence for a conformational change in a sensory receptor [PDF]
, 1977 A highly sensitive method for demonstrating ligand-induced conformational changes in protein molecules in solution is described. The method utilizes an environmentally sensitive reporter group that is known to be distant from the active site.
Hartig, P. R. +2 more
core
Ligand-receptor binding kinetics in surface plasmon resonance cells: A Monte Carlo analysis
, 2016 Surface plasmon resonance (SPR) chips are widely used to measure association and dissociation rates for the binding kinetics between two species of chemicals, e.g., cell receptors and ligands.
Carroll, Jacob +3 more
core +1 more source
Bioengineering models of cell signaling [PDF]
, 2000 Strategies for rationally manipulating cell behavior in cell-based technologies and molecular therapeutics and understanding effects of environmental agents on physiological systems may be derived from a mechanistic understanding of underlying signaling ...
Asthagiri, Anand R. +1 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The Biochemical Properties of Manganese in Plants
Plants, 2019 Manganese (Mn) is an essential micronutrient with many functional roles in plant metabolism. Manganese acts as an activator and co-factor of hundreds of metalloenzymes in plants.
Sidsel Birkelund Schmidt, Søren Husted
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Factors affecting light energy transfer in some samarium complexes
International Journal of Photoenergy, 2005 The photophysical properties of samarium ion in presence of 7-Acetoxy Coumarin 3-Carboxylic acid (ACC) or 1-(4-methoxyphenyl) 3-(4-t-butyl phenyl) 1,3-propandione (MBPK), which act as antenna of near-UV radiation, are studied in different homogeneous ...
Esam Bakier, M. S. A. Abdel-Mottaleb
doaj +1 more source
Evaluation of new antihypertensive drugs designed in silico using Thermolysin as a target
Saudi Pharmaceutical Journal, 2020 The search for new therapies for the treatment of Arterial hypertension is a major concern in the scientific community. Here, we employ a computational biochemistry protocol to evaluate the performance of six compounds (Lig783, Lig1022, Lig1392, Lig2177,
Desmond MacLeod-Carey +3 more
doaj +1 more source