Results 81 to 90 of about 373,653 (310)

Hedgehog on the Move: Glypican-Regulated Transport and Gradient Formation in Drosophila

Cells
Glypicans (Glps) are a family of heparan sulphate proteoglycans that are attached to the outer plasma membrane leaflet of the producing cell by a glycosylphosphatidylinositol anchor.
Carlos Jiménez-Jiménez, Kay Grobe, Isabel Guerrero   +2 more
doaj   +1 more source

Modulation of Ionotropic Glutamate Receptors and Acid-Sensing Ion Channels by Nitric Oxide

Frontiers in Physiology, 2012
Ionotropic glutamate receptors (iGluR) are ligand-gated ion channels and are densely expressed in broad areas of mammalian brains. Like iGluRs, acid-sensing ion channels (ASIC) are ligand (H+)-gated channels and are enriched in brain cells and ...
John Q Wang, Xiang-Ping eChu, Ming-Lei eGuo, Dao-Zhong eJin, Bing eXue, Thomas J Berry, Eugene E Fibuch, Li-Min eMao   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Imaging living obligate anaerobic bacteria with bilin-binding fluorescent proteins

Current Research in Microbial Sciences, 2020
Fluorescent tools such as green fluorescent protein (GFP) have been used extensively as reporters in biochemistry and microbiology, but GFP and other conventional fluorescent proteins are restricted to aerobic environments.
Hannah E. Chia, Tiancheng Zuo, Nicole M. Koropatkin, E. Neil G. Marsh, Julie S. Biteen   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

^1H{^(19)F} NOE NMR Structural Signatures of the Insulin R_6 Hexamer: Evidence of a Capped HisB10 Site in Aryl- and Arylacryloyl-carboxylate Complexes [PDF]

, 2009
New and improved insulin: ^1H{^(19)F} NOE NMR difference spectra for CF_3-substituted aromatic carboxylates bound at the HisB10 sites of the R_6 human insulin (HI) hexamer show strong NOEs between the CF_3 groups and the LeuB6, AsnB3, and PheB1 ...
Bonaccio, Maria, Borchardt, Dan, Dunn, Michael F., Ghaderi, Nima, Keidel, Donald, Niks, Dimitri   +5 more
core  

Spectroscopic and Mechanistic Studies of Heterodimetallic Forms of Metallo-β-lactamase NDM-1 [PDF]

, 2014
In an effort to characterize the roles of each metal ion in metallo-β-lactamase NDM-1, heterodimetallic analogues (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated and characterized. UV–vis, 1H NMR, EPR, and EXAFS spectroscopies were used to confirm
Alyssa Hetrick, Ambler R. P., Amy R. Marts, Ankudinov A. L., Badarau A., Banci L., Bebrone C., Bennett B., Bertini I., Bertini I., Bertini I., Bertini I., Bicknell R., Bienvenue D. L., Bonomo R. A., Breece R. M., Brian Bennett, Carfi A., Copick A. J., Cricco J. A., Crisp J., Crowder M. W., Crowder M. W., David L. Tierney, Dennison C., Dennison C., deSeny D., Docobo-Perez F., Docquier J. D., Doi Y., Donaire A., Donaire A., Drawz S. M., Fernandez C. O., Fisher J. F., Garcia-Saez I., Garmer D. R., Garrity J. D., Garrity J. D., González J. M., Griffin D. H., Hao Yang, Hawk M. J., Hernandez V., Hu Z., Huang C. C., Huntington K. M., Kim Y., King D., Koh T. H., Kumarasamy K. K., Li T., Lisa M. N., Livermore D. M., Llarrull L. I., Llarrull L. I., Mahesh Aitha, McManus-Munoz S., Michael W. Crowder, Momb J., Orellano E. G., Papp-Wallace K. M., Park H., Periyannan G., Piccioli M., Prescott J. M., Reid T. S., Renault J. P., Riley E. A., Saini A., Salgado J., Sharma N., Sharma N. P., Spencer J., Stamper C., Strynadka N. C. J., Thakur P. K., Thomas P. W., Thomas P. W., Tioni M. F., Toney J. H., Ullah J. H., Vila A. J., Vila A. J., Wang Z., Wang Z., Worthington R. J., Xu D., Yamaguchi Y., Yang H., Yong D., Yuan Q., Zhang H., Zheng B., Zhu K.   +94 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source