Results 51 to 60 of about 373,653 (310)

A Five-coordinate Metal Center in Co(II)-substituted VanX [PDF]

, 2005
In an effort to structurally probe the metal binding site in VanX, electronic absorption, EPR, and extended x-ray absorption fine structure (EXAFS) spectroscopic studies were conducted on Co(II)-substituted VanX.
Bennett, Brian, Breece, Robert M., Costello, Alison L., Crowder, Michael W., Matthews, Megan L., Sigdel, Tara K., Tierney, David L.   +6 more
core   +1 more source

A Diffusion-Based Approach to Geminate Recombination of Heme Proteins with Small Ligands [PDF]

, 2002
A model of postphotodissociative monomolecular (geminate) recombination of heme proteins with small ligands (NO, O2 or CO) is represented. The non-exponential decay with time for the probability to find a heme in unbound state is interpreted in terms of ...
Abadan, Anfinrud, Ansari, Ansari, Antonioni, Austin, Baldwin, Berlin, Bonaventura, Bruha, Cameron, Case, Chernoff, Cotes, Dadusc, Das, Dasgupta, Doster, Dzhagarov, Dzhagarov, Dzhagarov, Dzhagarov, Eaton, Elber, Fermi, Frauenfelder, Frauenfelder, Frauenfelder, Gallo, Gibson, Gibson, Hasinoff, Henry, Ho, Horbach, Johnson, Johnson, Jost, Kimanaka, Kottalam, Kuczera, Lepeshkevich, Lim, Lindqvist, Lukin, Marden, Morris, Muller, Murray, Olson, Olson, Perutz, Perutz, Perutz, Petrich, Potter, Quillin, Rifkind, Rodgers, Schaad, Schlichting, Shaanan, Springer, Starovoitov, Steinbach, Steinbach, Straub, Yamamoto, Yang, Ye   +69 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Application of CoLD-CoP to Detecting Competitively and Cooperatively Binding Ligands

Biomolecules
NMR utilization in fragment-based drug discovery requires techniques to detect weakly binding fragments and to subsequently identify cooperatively binding fragments. Such cooperatively binding fragments can then be optimized or linked in order to develop
Shiva V. Patnala, Roberto Robles, David A. Snyder   +2 more
doaj   +1 more source

Current Applications and Future Perspectives of CRISPR-Cas9 for the Treatment of Lung Cancer

Biologics: Targets & Therapy, 2021
Markeshaw Tiruneh G/Medhin,1 Endeshaw Chekol Abebe,2 Tekeba Sisay,3 Nega Berhane,3 Tesfahun Bekele Snr,1 Tadesse Asmamaw Dejenie1 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar ...
Tiruneh G/Medhin M, Chekol Abebe E, Sisay T, Berhane N, Bekele Snr T, Asmamaw Dejenie T   +5 more
doaj  

Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release

Nanomaterials, 2017
Present study refers to the synthesis of new advanced materials based on poly(methacrylic acid) (PMAA) with previously reported own advanced modified clays by edge covalent bonding.
Raluca Ianchis, Claudia M. Ninciuleanu, Ioana C. Gifu, Elvira Alexandrescu, Raluca Somoghi, Augusta R. Gabor, Silviu Preda, Cristina L. Nistor, Sabina Nitu, Cristian Petcu, Madalina Icriverzi, Paula E. Florian, Anca M. Roseanu   +12 more
doaj   +1 more source

How many metals does it take to fix N2? A mechanistic overview of biological nitrogen fixation [PDF]

, 2006
During the process of biological nitrogen fixation, the enzyme nitrogenase catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Nitrogenase consists of two component metalloproteins, the iron (Fe) protein and the molybdenum-iron (MoFe) protein;
Howard, James B., Rees, Douglas C.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Gain–of–Function Genetic Models to Study FSH Action

Frontiers in Endocrinology, 2019
Follicle–stimulating hormone (FSH) is a pituitary-derived gonadotropin that plays key roles in male and female reproduction. The physiology and biochemistry of FSH have been extensively studied for many years.
Rosemary McDonald, Rosemary McDonald, Carolyn Sadler, T. Rajendra Kumar, T. Rajendra Kumar, T. Rajendra Kumar   +5 more
doaj   +1 more source

Advances in thiosemicarbazone metal complexes as anti-lung cancer agents

Frontiers in Pharmacology, 2022
The great success of cisplatin as a chemotherapeutic agent considerably increased research efforts in inorganic biochemistry to identify more metallic drugs having the potential of treating lung cancer.
Xian-Guang Bai, Yunyun Zheng, Jinxu Qi
doaj   +1 more source