Quasispecies-like behavior observed in catalytic RNA populations evolving in a test tube [PDF]
, 2010 Background: During the RNA World, molecular populations were probably very small and highly susceptible to the force of strong random drift. In conjunction with Muller\u27s Ratchet, this would have imposed difficulties for the preservation of the genetic
Díaz Arenas, Carolina, Lehman, Niles
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Novel Mechanism for Priming Aromatic Polyketide Synthases [PDF]
, 2004 In this issue of Chemistry & Biology, a novel priming mechanism is proposed for aromatic polyketide biosynthesis, with an iterative type I polyketide synthase generating a starter unit primed for a type II polyketide synthase [6].
Salas, José A
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Optimization and optimality of a short ribozyme ligase that joins non-Watson–Crick base pairings
RNA, 2001 A small ribozyme ligase (L1) selected from a random sequence population appears to utilize non-Watson-Crick base pairs at its ligation junction. Mutational and selection analyses confirmed the presence of these base pairings. Randomization of the L1 core and selection of active ligases yielded highly active variants whose rates were on the order of 1 ...
Jay R. Hesselberth +2 more
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Ribozymes of the RNA World: Investigating Ancient Enzymes through Modern Self-Cleaving Ribozymes. [PDF]
, 2016 Ribozymes are RNAs that can perform catalytic functions. The discovery of ribozymes was an important milestone in science because it not only opened new avenues of research but also provided insights into the origins of life on Earth.
Mir, Aamir
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Protecting the proteome: Eukaryotic cotranslational quality control pathways. [PDF]
, 2014 The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task. The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on
Bennett, Eric J, Lykke-Andersen, Jens
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, 2004 Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts.
Cedergren, Robert J. +4 more
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Molecular Crowding Facilitates Ribozyme-Catalyzed RNA Assembly. [PDF]
ACS Cent Sci, 2023 DasGupta S, Zhang S, Szostak JW.
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Programming anti-ribozymes to sense trigger RNAs for modulating gene expression in mammalian cells. [PDF]
Synth Syst BiotechnolZhang W +5 more
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Development of a Functionally Minimized Mutant of the R3C Ligase Ribozyme Offers Insight into the Plausibility of the RNA World Hypothesis. [PDF]
Biology (Basel), 2014 Kurihara E +3 more
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Circular mRNA: A novel therapeutic agent. [PDF]
Biotechnol Notes, 2023 Wang X, Dong J, Lu Y.
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