Escalation of error catastrophe for enzymatic self-replicators [PDF]
, 2007 It is a long-standing question in origin-of-life research whether the information content of replicating molecules can be maintained in the presence of replication errors.
B. Obermayer +5 more
core +2 more sources
Selective Nonenzymatic Formation of Biologically Common RNA Hairpins
Angewandte Chemie, Volume 137, Issue 5, January 27, 2025.Template‐free RNA loop‐closing ligation selectively generates RNA tetraloops that are prevalent in biology, as demonstrated by high‐throughput sequencing. Utilizing high‐yield overhang sequences enables the efficient assembly of functional RNAs. Abstract The prebiotic formation of RNA building blocks is well‐supported experimentally, yet the emergence ...
Long‐Fei Wu +5 more
wiley +1 more source
The effect of cytidine on the structure and function of an RNA ligase ribozyme
RNA, 2001 A cytidine-free ribozyme with RNA ligase activity was obtained by in vitro evolution, starting from a pool of random-sequence RNAs that contained only guanosine, adenosine, and uridine. This ribozyme contains 74 nt and catalyzes formation of a 3',5'-phosphodiester linkage with a catalytic rate of 0.016 min(-1).
J, Rogers, G F, Joyce
openaire +3 more sources
The Implementation and Efficacy of Scientific Literature within an Introductory Biology Lecture Course:A Study in Pedagogy, Curricula, and Standards as They Apply to Post-Secondary Science Education [PDF]
, 2009 The current study involved students enrolled in the Fall 2007 Biosc 0150 and Spring 2008 Biosc 0160 lecture sections of a single Faculty member. Most students were incoming freshmen, and their prior exposure to the natural sciences varied.
Tomaszewski, Shaun Allen
core
In Vitro Selection of a New Lanthanide-Dependent DNAzyme for Ratiometric Sensing Lanthanides [PDF]
, 2014 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, copyright © American Chemical Society after peer review and technical editing by publisher. To access the final edited and published
Huang, Po-Jung Jimmy +2 more
core +1 more source
Capturing the ‘ome’ : the expanding molecular toolbox for RNA and DNA library construction [PDF]
, 2018 All sequencing experiments and most functional genomics screens rely on the generation of libraries to comprehensively capture pools of targeted sequences.
Boone, Morgane +2 more
core +2 more sources
Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection [PDF]
, 2015 published_or_final_versio
Cheung, YW +7 more
core +2 more sources
Mini-ribozymes and freezing environment: a new scenario for the early RNA world
, 2005 International audienceThe RNA World hypothesis states that the present-day life, which is based on DNA genomes and protein enzymes, was preceded by a simpler life form based primarily on RNA.
Vlassov, A. V.
core +1 more source
Continual reproduction of self-assembling oligotriazole peptide nanomaterials. [PDF]
, 2017 Autocatalytic chemical reactions, whereby a molecule is able to catalyze its own formation from a set of precursors, mimic nature's ability to generate identical copies of relevant biomolecules, and are thought to have been crucial for the origin of life.
Brea, Roberto J, Devaraj, Neal K
core +2 more sources
Correcting pervasive errors in RNA crystallography through enumerative structure prediction
, 2012 Three-dimensional RNA models fitted into crystallographic density maps exhibit pervasive conformational ambiguities, geometric errors and steric clashes. To address these problems, we present enumerative real-space refinement assisted by electron density
AT Brunger +27 more
core +1 more source