RNA ligase ribozymes with a small catalytic core
RNA ligase ribozymes with a small catalytic coreCatalytic RNAs, or ribozymes, catalyze diverse chemical reactions that could have sustained primordial life in the hypothetical RNA world. Many natural ribozymes and laboratory evolved ribozymes exhibit efficient catalysis mediated by elaborate catalytic cores within complex tertiary structures.
openaire
Evolutionary optimization of a modular ligase ribozyme: a small catalytic unit and a hairpin motif masking an element that could form an inactive structure [PDF]
, 2010 Yuki Fujita +2 more
openalex +1 more source
Derailing the host machinery to achieve replication: how viroid and viroid-like RNAs successfully copy their genomes in hostile territory. [PDF]
RNA BiolKalantidis K +5 more
europepmc +1 more source
Metastable Folding of Bacillus subtilis glmS Ribozyme Modulates Turnover by RNase J1. [PDF]
J Mol BiolLou Y, Woodson SA.
europepmc +1 more source
RNA denaturation underlies circular RNA separation. [PDF]
Nucleic Acids ResJiang Y, Kjems J.
europepmc +1 more source
Exploring the space of self-reproducing ribozymes using generative models. [PDF]
Nat CommunLambert CN +8 more
europepmc +1 more source
Fitness landscapes and thermodynamic approaches to development of nucleic acids enzymes: from classical methods to AI integration. [PDF]
RSC Chem BiolTakahashi S +3 more
europepmc +1 more source
A class I ligase ribozyme with reduced Mg2+ dependence: Selection, sequence analysis, and identification of functional tertiary interactions [PDF]
, 2009 Sarah C. Bagby +4 more
openalex +1 more source
Cross-chiral exponential amplification of an RNA enzyme. [PDF]
Proc Natl Acad Sci U S ACochrane WG +3 more
europepmc +1 more source