The first peptides: the evolutionary transition between prebiotic amino acids and early proteins [PDF]
, 2009 The issues we attempt to tackle here are what the first peptides did look like when they emerged on the primitive earth, and what simple catalytic activities they fulfilled.
Buhrman, Harry +4 more
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Correction to Supporting Information for Walton et al., In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates [PDF]
, 2021 openalex +1 more source
Biochemical Characterization of a Lanthanide-Dependent DNAzyme with Normal and Phosphorothioate-Modified Substrates [PDF]
, 2015 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biochemistry, copyright © American Chemical Society after peer review and technical editing by publisher.
Huang, Po-Jung Jimmy +3 more
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Witnessing the Evolution of RNA [PDF]
, 2022 The RNA World theory postulates that at a certain point around 4 billion years ago during an RNA World period, a molecule, possibly RNA, developed the ability to self-replicate via polymerization.
Portillo, Xavier
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How to build a living thing [PDF]
, 2009 Thesis (S.M. in Science Writing)--Massachusetts Institute of Technology, Dept. of Humanities, Graduate Program in Science Writing, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p.
Campbell, MacGregor (MacGregor Ballard)
core
Correcting pervasive errors in RNA crystallography through enumerative structure prediction
, 2012 Three-dimensional RNA models fitted into crystallographic density maps exhibit pervasive conformational ambiguities, geometric errors and steric clashes. To address these problems, we present enumerative real-space refinement assisted by electron density
AT Brunger +27 more
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The nonenzymatic template-directed ligation of oligonucleotides
, 2006 International audienceThe nonenzymatic template-directed ligation of oligonucleotides containing 2',3'-cyclic phosphate was investigated in the presence of divalent cations. Ligation of the oligonucleotides readily occurred in the presence of Mg2+, Mn2+,
Chernolovskaya, E. L. +3 more
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Local Neutral Networks Help Maintain Inaccurately Replicating Ribozymes [PDF]
, 2014 The error threshold of replication limits the selectively maintainable genome size against recurrent deleterious mutations for most fitness landscapes.
Kun, Ádám +2 more
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T. thermophila group I introns that cleave amide bonds [PDF]
, 1997 The present invention relates to nucleic acid enzymes or enzymatic RNA molecules that are capable of cleaving a variety of bonds, including phosphodiester bonds and amide bonds, in a variety of substrates.
Joyce, Gerald F.
core +1 more source