Results 171 to 180 of about 73,558 (196)
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A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase.

Nature structural biology, 2001
The hammerhead ribozyme is a more efficient ribonuclease than an RNA ligase. Under typical reaction conditions, the rate of RNA chain cleavage is approximately 100-fold faster than the rate of the reverse ligation reaction such that virtually all of the hammerhead is in its cleaved form at equilibrium.
Olke C. Uhlenbeck   +1 more
openaire   +3 more sources

Effects of complementary loop composition in truncated R3C ligase ribozymes on kiss switch activation

Biosystems, 2019
The formation of a kissing-loop through the introduction of complementary 7-membered loops is known to dramatically increase the activity of truncated R3C ligase ribozymes that otherwise display reduced activity. Restoration of activity is thought to result from kissing complex formation-induced rearrangement of two molecules with complementary loops ...
Kana Tanizawa   +5 more
openaire   +3 more sources

In vitro selection of novel ligase ribozymes [PDF]

open access: possibleOrigins of life and evolution of the biosphere, 1996
Jack W. Szostak, Alicia J. Hager
openaire   +1 more source

E3 ligase ligand chemistries: from building blocks to protein degraders

Chemical Society Reviews, 2022
Izidor Sosi   +2 more
exaly  

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

Frontiers in Chemistry, 2021
Aleša Bricelj   +2 more
exaly  

SCF ubiquitin ligase-targeted therapies

Nature Reviews Drug Discovery, 2014
Julia K Pagan, Michele Pagano
exaly  

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

Nature, 2014
Eric S Fischer   +2 more
exaly  

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