Results 171 to 180 of about 73,558 (196)
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A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase.
Nature structural biology, 2001The hammerhead ribozyme is a more efficient ribonuclease than an RNA ligase. Under typical reaction conditions, the rate of RNA chain cleavage is approximately 100-fold faster than the rate of the reverse ligation reaction such that virtually all of the hammerhead is in its cleaved form at equilibrium.
Olke C. Uhlenbeck+1 more
openaire +3 more sources
Biosystems, 2019
The formation of a kissing-loop through the introduction of complementary 7-membered loops is known to dramatically increase the activity of truncated R3C ligase ribozymes that otherwise display reduced activity. Restoration of activity is thought to result from kissing complex formation-induced rearrangement of two molecules with complementary loops ...
Kana Tanizawa+5 more
openaire +3 more sources
The formation of a kissing-loop through the introduction of complementary 7-membered loops is known to dramatically increase the activity of truncated R3C ligase ribozymes that otherwise display reduced activity. Restoration of activity is thought to result from kissing complex formation-induced rearrangement of two molecules with complementary loops ...
Kana Tanizawa+5 more
openaire +3 more sources
In vitro selection of novel ligase ribozymes [PDF]
Jack W. Szostak, Alicia J. Hager
openaire +1 more source
E3 ligase ligand chemistries: from building blocks to protein degraders
Chemical Society Reviews, 2022Izidor Sosi+2 more
exaly
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Frontiers in Chemistry, 2021Aleša Bricelj+2 more
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SCF ubiquitin ligase-targeted therapies
Nature Reviews Drug Discovery, 2014Julia K Pagan, Michele Pagano
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Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
Nature, 2014Eric S Fischer+2 more
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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Nature, 2004L Aravind+2 more
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