Results 151 to 160 of about 86,842 (296)

Structural Basis for the N-Terminal Capping onto the Ribosomal Peptide by Novel Peptide Ligase PGM1

, 2017
Takashi Matsui
openalex   +2 more sources

Expression of a DNA‐ligase‐stimulatory factor in Bloom's syndrome cell line GM1492 [PDF]

, 1988
Kerstin Kenne, Siv Ljungquist
openalex   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

MARCH7 E3 ubiquitin ligase is highly expressed in developing spermatids of rats and its possible involvement in head and tail formation

, 2013
博強 趙
openalex   +1 more source

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

The multifaceted role of E3 ubiquitin ligases in cancer metastasis: mechanisms, targets, and therapeutic implications. [PDF]

Essays Biochem
Singh M, Upreti A, Chattopadhyay S, Santra M.   +3 more
europepmc   +1 more source

Np95 Is a Histone-Binding Protein Endowed with Ubiquitin Ligase Activity

, 2004
Elisabetta Citterio, Roberto Papait, Francesco Nicassio, Manuela Vecchi, Paola Gomiero, Roberto Mantovani, Pier Paolo Di Fiore, Ian Marc Bonapace   +7 more
openalex   +2 more sources

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Multi-scale classification decodes the complexity of the human E3 ligome. [PDF]

Nat Commun
Dutta A, Cristiani A, Nikte SV, Eisert J, Matthess Y, Markusic B, Tudose C, Becht C, Cetin R, Shah VJ, Mosler T, Husnjak K, Dikic I, Kaulich M, Bhaskara RM.   +14 more
europepmc   +1 more source

HIV1 Vpr Arrests the Cell Cycle by Recruiting DCAF1/VprBP, a Receptor of the Cul4-DDB1 Ubiquitin Ligase [PDF]

, 2007
Erwann Le Rouzic, Nadia Belaïdouni, Emilie Estrabaud, Marina Morel, Jean‐Christophe Rain, Catherine Transy, Florence Margottin-Goguet   +6 more
openalex   +1 more source