Results 171 to 180 of about 143,768 (336)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

The dual role of the ubiquitin-proteasome system in photomorphogenesis. [PDF]

Essays Biochem
Zhou H, Deng XW.
europepmc   +1 more source

Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease [PDF]

Janina Lara Gerber, Suria Itzel Morales-Guzman, Lorenz Worf, Petra Hubbe, Jürgen Kopp, Jirka Peschek   +5 more
openalex   +1 more source

Effect of Alanine, Leucine, and Fructose on Lysyl-Transfer Ribonucleic Acid Ligase Activity in a Mutant of Escherichia coli K-12 [PDF]

, 1973
Irvin N. Hirshfield, Naomi E. Buklad
openalex   +1 more source

Ubiquitin ligases in oncogenic transformation and cancer therapy

Nature Reviews. Cancer, 2017
D. Senft, Jianfei Qi, Z. Ronai
semanticscholar   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, EarlyView.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Glutamate Cysteine Ligase—Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage [PDF]

, 2016
Suzie Lavoie, Pascal Steullet, Anita Kulak, Frédéric Preitner, Kim Q., Pierre J. Magistretti   +5 more
openalex   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, EarlyView.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
wiley   +1 more source

Ubiquitin E3 Ligases and p53 in Doxorubicin-Induced Cardiotoxicity. [PDF]

Int J Mol Sci
Tachibana S, Otaki Y, Goto J, Watanabe T, Watanabe M.   +4 more
europepmc   +1 more source

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta [PDF]

, 2019
Joanna Kud, Wenjie Wang, Yulin Yuan, Allan Caplan, Joseph C. Kuhl, Louise‐Marie Dandurand, Fangming Xiao   +6 more
openalex   +1 more source