Results 271 to 280 of about 120,350 (347)

Expanding the Scope of Molecular Glues: TRIM21 as a Multimeric Protein Degrader. [PDF]

MedComm (2020)
Huang K, Zhou A, Zhou X.
europepmc   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit

Angewandte Chemie, EarlyView.
A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo, Aman Ishaqat, Junlin Chen, Fabian Wiertz, Adrian Kuzmanović, Matthias Bartneck, Fabian Kiessling, Andreas Herrmann   +7 more
wiley   +2 more sources

Identification of E3 ubiquitin ligase-based molecular subtypes and prognostic signature regarding prognosis and immune landscape in bladder cancer. [PDF]

Cancer Cell Int
Hu B, Zhao T, Li Y, Li K, Shen L, Zhu Q, Ma B, Wei Y.   +7 more
europepmc   +1 more source

Biocatalytic Isocitrate Production from Low‐Concentration Gaseous CO2 and Biobased 2‐Oxogultarate

Advanced Energy and Sustainability Research, EarlyView.
Biocatalytic isocitrate production from 2‐oxoglutarate and low‐concentration CO2 below 5% in the presence of NADPH and manganese ion was developed. Isocitrate dehydrogenase (IDH) from yeast (EC 1.1.1.42) is an enzyme that catalyzes the decarboxylating isocitrate into 2‐oxogurtarate and carbon dioxide and the reverse process of the introducing carbon ...
Masamichi Hino, Yutaka Amao
wiley   +1 more source

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +2 more sources

Ubiquitination in lipid metabolism reprogramming: implications for pediatric solid tumors. [PDF]

Front Immunol
Zhang W, Xu Y, Fang Y, Li M, Li D, Guo H, Li H, He J, Miao L.   +8 more
europepmc   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Development of an Organoautocatalyzed Double σ‐Bond C(sp2)‐N Transamination Metathesis Reaction

Angewandte Chemie, EarlyView.
Organoautocatalyzed transamination metathesis of cyclic tertiary amines is disclosed as a high‐yielding, scalable reaction that proceeds under mild, catalyst‐free conditions. It operates via a multi‐step domino reaction mechanism, where an in situ‐formed pyrrolidinium salt functions as a HBD organoautocatalyst.
Volker Klein, Florian Schuster, Jonas Amthor, Harald Maid, Prabhakar Bijalwan, Fahmi Himo, Stefano Santoro, Svetlana B. Tsogoeva   +7 more
wiley   +2 more sources

A Novel Prognostic Signature of Mitophagy-Related E3 Ubiquitin Ligases in Breast Cancer. [PDF]

Int J Mol Sci
Bian K, Yang C, Zhang F, Huang L.
europepmc   +1 more source