Results 271 to 280 of about 125,351 (338)

Aberrant cohesin function in Saccharomyces cerevisiae activates Mcd1 degradation to promote cell lethality. [PDF]

PLoS Genet
Singh G, Skibbens RV.
europepmc   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain. [PDF]

Sci Rep
Liu H, Francis L, Dagley LF, Cobbold SA, Webb AI, Komander D, Villadangos JA, Mintern JD.   +7 more
europepmc   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

Multi-center multi-omics integration predicts individualized prognosis in medullary thyroid carcinoma. [PDF]

Nat Commun
Zhou Y, Wang Y, Shi X, Wang J, Zang Z, Zhang L, Gui Z, Cai X, Hu P, Wang J, Liu H, Wang Z, Guan H, Wu X, Shen C, He Y, Li M, Zhang H, Wang J, Wu Y, Chen C, Zhu Y, Sun Y, Liu Z, Wang Y, Guo T.   +25 more
europepmc   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators. [PDF]

Adv Sci (Weinh)
Martínez-Cartró M, Serrano-Morrás Á, Bertran-Mostazo A, Castaño-Muñiz R, Scaffidi S, Ivanova V, Csorba N, Simon J, Ábrányi-Balogh P, Li Y, Keserü GM, Hao B, Barril X, Galdeano C.   +13 more
europepmc   +1 more source

Epidermal Cell Dynamics Regulates Rice Lamina Joint Morphogenesis and Leaf Angle Formation through OsZHD1 and OsZHD2 Regulation

Advanced Science, EarlyView.
The lamina joint determines leaf angle and plant architecture. Xu et al. establish a live‐imaging system for the rice lamina joint and reveal that asymmetric epidermal cell elongation and division between the lateral and medial edges drive leaf angle formation.
Yiru Xu, Heng Zhou, Xiaojiang Wu, Wuyu Cui, Shouling Xu, Xi He, Dan Xiang, Ming Zhou, Xiuqin Rao, Lilan Hong   +9 more
wiley   +1 more source

The E3 ligase MEX3B forms a tripartite complex with <i>Rest</i> and <i>Hotair</i> to determine the proliferative capacity of neural progenitor cells. [PDF]

Open Biol
Garg K, Sharma G, Samaddar S, Banerjee S.   +3 more
europepmc   +1 more source