Results 281 to 290 of about 143,768 (336)

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

Advanced Science, EarlyView.
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao, Yuting Du, Danxia Zhou, Meng Bai, Xu Gao, Zhenyue Hao, Nan‐Jie Xu, Jiaqiang Liu, Ying Huang, Zhenji Gan, Jing Zhang   +10 more
wiley   +1 more source

Protective Effects of Quinic Acid Against Disuse-Induced Skeletal Muscle Atrophy via Regulation of Inflammation and Oxidative Stress. [PDF]

Foods
Kim MB, Lee H, Kang J, Kim B, Hwang JK.
europepmc   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Functional Analysis of the Pepper RING-Type E3 Ligase CaANKR1 Involved in Drought Stress Tolerance via Modulation of Abscisic Acid Signaling. [PDF]

Physiol Plant
Kim M, Lim CW, Kim DS, Lee SC.
europepmc   +1 more source

Carnosine ameliorates dexamethasone-induced muscle atrophy with associated modulation of ubiquitin ligases and oxidative stress in C57BL/6J female mice. [PDF]

Curr Res Physiol
Rahman MM, Ulla A, Ogura H, Tsuda H, Uchida T, Fukawa T, Nikawa T.   +6 more
europepmc   +1 more source

Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2. [PDF]

RSC Chem Biol
Kennedy CR, McPhie KA, Vuorinen A, Dudley-Fraser J, Esposito D, Maslen S, McCarthy WJ, Pettinger J, Skehel JM, Bush J, House D, Rittinger K.   +11 more
europepmc   +1 more source

Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control. [PDF]

Science
Grabarczyk DB, Ehrmann JF, Murphy P, Yang WS, Kurzbauer R, Bell LE, Deszcz L, Neuhold J, Schleiffer A, Shulkina A, Lee J, Shin JS, Meinhart A, Versteeg GA, Zavodszky E, Song HK, Hegde RS, Clausen T.   +17 more
europepmc   +1 more source

Decoding LAG3 activation: ubiquitination liberates immunosuppressive motif to license checkpoint function. [PDF]

Mol Biomed
Zhang T, Xie F, Zhou F.
europepmc   +1 more source

Modulating Parkin E3 Ubiquitin Ligase Activity Using Phospho-Ubiquitin Variants

, 2016
Susanna George
openalex   +1 more source