Results 281 to 290 of about 120,350 (347)

Small Molecule‐Induced Alterations of Protein Polyubiquitination Revealed by Mass‐Spectrometric Ubiquitome Analysis

Angewandte Chemie, EarlyView.
To monitor small molecule‐induced changes in protein polyubiquitination in an unbiased manner, we employ enrichment through tandem ubiquitin binding entities coupled to LC‐MS/MS analysis (TUBE‐MS). By applying the workflow to PROTAC, p97‐ and deubiquitinase‐inhibitor treatment of cells, we demonstrate its broad applicability and reveal the induction of
Siska Führer, Kai Gallant, Farnusch Kaschani, Markus Kaiser, Petra Janning, Herbert Waldmann, Malte Gersch   +6 more
wiley   +2 more sources

Ubiquitination in hepatocellular carcinoma immunity. [PDF]

J Transl Med
Zhao J, Li Y, Zhu J, Li H, Jin X.
europepmc   +1 more source

Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry

Angewandte Chemie, EarlyView.
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou, Chenbo Sun, Weitao Chen, Hanyu Gao, Fei Sun   +4 more
wiley   +2 more sources

Repair pathway coordination from gap filling by polβ and subsequent nick sealing by LIG1 or LIG3α governs BER efficiency at the downstream steps. [PDF]

DNA Repair (Amst)
Çağlayan M.
europepmc   +1 more source

Conditional Stabilization of the Hypoxia‐Inducible Factor HIF1α— Photoswitchable Stapled Peptides Prevent Elongin BC–Mediated Degradation

Angewandte Chemie, EarlyView.
Visible‐light photoswitchable peptides enable the stabilization of the hydroxylated hypoxia transcription factor 1α (HIF1α—OH) by targeting the pVHL‐EloBC interaction. Significant differences in conformation, binding, and transcription of HIF‐targeted genes between the photostationary states (PSS) were demonstrated.
Van Tuan Trinh, Sabrina Fischer, Lei Zhang, Heiko Geisler, Belen Pardo, Robert Liefke, Frank Abendroth, Olalla Vázquez   +7 more
wiley   +2 more sources

Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check. [PDF]

Front Immunol
Gong M, Luo J, Liang Q, Liu Y, Zheng Y, Yang XD.   +5 more
europepmc   +1 more source

A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins. [PDF]

Cancers (Basel)
Ganesan IP, Kiyokawa H.
europepmc   +1 more source

The ubiquitin ligase NKLAM promotes apoptosis and suppression of cell growth. [PDF]

J Biol Chem
Willard PA, Kornbluth J.
europepmc   +1 more source

HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function. [PDF]

J Virol
Qiu L, Gao X, Shao X, Xi J, Chen S, Pham T, Wang Y, Dong J, Rao SD, Hao J, Lo JH, Yang R, Engel EA, Crump CM, Yuan W.   +14 more
europepmc   +1 more source