Results 41 to 50 of about 143,768 (336)

Chain reactions: molecular mechanisms of RBR ubiquitin ligases

Biochemical Society Transactions, 2020
Ubiquitination is a fundamental post-translational modification that regulates almost all aspects of cellular signalling and is ultimately catalysed by the action of E3 ubiquitin ligases.
T. Cotton, B. C. Lechtenberg
semanticscholar   +1 more source

CRL Ubiquitin Ligases and DNA Damage Response

Frontiers in Oncology, 2012
Cullin/RING ubiquitin ligases (CRL) comprise the largest subfamily of ubiquitin ligases and are involved in various biological processes. One of the main functions of CRLs is to regulate DNA damage response, a fundamental signaling cascade to maintain ...
Jianping eJin, Ju-Mei eLi
doaj   +1 more source

A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. [PDF]

PLoS ONE, 2017
Ubiquitination is a crucial post-translational modification that can target proteins for degradation. The E3 ubiquitin ligases are responsible for recognizing substrate proteins for ubiquitination, hence providing specificity to the process of protein ...
Kwami F Ketosugbo, Henry L Bushnell, Ruth I Johnson   +2 more
doaj   +1 more source

Regulation of Arabidopsis photoreceptor CRY2 by two distinct E3 ubiquitin ligases

Nature Communications, 2020
Cryptochromes (CRYs) are photoreceptors or components of the molecular clock in various evolutionary lineages, and they are commonly regulated by polyubiquitination and proteolysis.
Yadi Chen, Xiaohuan Hu, Siyuan Liu, Tiantian Su, Hsiaochi Huang, Huibo Ren, Zhensheng Gao, Xu Wang, Deshu Lin, J. Wohlschlegel, Qin Wang, Chentao Lin   +11 more
semanticscholar   +1 more source

Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns

BMC Gastroenterology, 2022
Background Ubiquitin ligases (Ub-ligases) are essential intracellular enzymes responsible for the regulation of proteome homeostasis, signaling pathway crosstalk, cell differentiation and stress responses.
Veronika Iatsiuk, Frantisek Malinka, Marketa Pickova, Jolana Tureckova, Jiri Klema, Frantisek Spoutil, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek   +8 more
doaj   +1 more source

The Role of HECT E3 Ubiquitin Ligases in Colorectal Cancer

Biomedicines, 2023
Colorectal cancer (CRC) is estimated to rank as the second reason for cancer-related deaths, and the prognosis of CRC patients remains unsatisfactory. Numerous studies on gastrointestinal cell biology have shown that the E3 ligase-mediated ubiquitination
Aiqin Sun, Yifei Chen, Xianyan Tian, Qiong Lin   +3 more
doaj   +1 more source

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Science, 2019
Divergent protein kinase SidJ is a protein produced by Legionella pneumophila that orchestrates this intracellular pathogen's establishment within the host cell.
M. Black, A. Osinski, Marcin Gradowski, Kelly A. Servage, K. Pawłowski, D. Tomchick, V. Tagliabracci   +6 more
semanticscholar   +1 more source

Exploration of Aberrant E3 Ligases Implicated in Alzheimer’s Disease and Development of Chemical Tools to Modulate Their Function

Frontiers in Cellular Neuroscience, 2021
The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process involves a cascade of ubiquitin (Ub) transfer steps from E1 to E2 to E3 ligase.
Frances M. Potjewyd, Alison D. Axtman
doaj   +1 more source

Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress

Journal of Translational Internal Medicine, 2020
Ubiquitination is a modification after protein transcription that plays a vital role in maintaining the homeostasis of the cellular environment. The Homologous to E6AP C-terminus (HECT) family E3 ubiquitin ligases are a kind of E3 ubiquitin ligases with ...
Hao Qian, Ying Zhang, Boquan Wu, Shaojun Wu, Shilong You, Naijin Zhang, Yingxian Sun   +6 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source