Reinforcement Learning-Driven Linker Design via Fast Attention-based Point Cloud Alignment [PDF]
arXiv, 2023 Proteolysis-Targeting Chimeras (PROTACs) represent a novel class of small molecules which are designed to act as a bridge between an E3 ligase and a disease-relevant protein, thereby promoting its subsequent degradation. PROTACs are composed of two protein binding "active" domains, linked by a "linker" domain.
arxiv
Poly(dA:dT)-rich DNAs are highly flexible in the context of DNA looping [PDF]
PLOS ONE 8(10): e75799, 2013 Large-scale DNA deformation is ubiquitous in transcriptional regulation in prokaryotes and eukaryotes alike. Though much is known about how transcription factors and constellations of binding sites dictate where and how gene regulation will occur, less is known about the role played by the intervening DNA. In this work we explore the effect of sequence
arxiv +1 more source
Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases [PDF]
PeerJ, 2016 The ubiquitin-proteasome system targets misfolded proteins for degradation. Since the accumulation of such proteins is potentially harmful for the cell, their prompt removal is important.
Wouter Boomsma +4 more
doaj +2 more sources
Biology Direct, 2009 Background Eukaryotic Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) encode most if not all of the enzymes involved in their DNA replication. It has been inferred that genes for these enzymes were already present in the last common ancestor of the NCLDV ...
Koonin Eugene V, Yutin Natalya
doaj +1 more source
E3 Ubiquitin Ligases and Their Therapeutic Applications in Cancers: Narrative Review
Journal of Pharmacy and Bioallied SciencesE3 ubiquitin ligases are a class of enzymes, essential for maintaining the equilibrium of cells by binding ubiquitin molecules to substrates to mark them for destruction.
Azfar Jamal
doaj +1 more source
E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration
Frontiers in Molecular Neuroscience, 2017 Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to neurodegeneration and aging.
Arun Upadhyay +6 more
doaj +1 more source
Research Progress on the Role of E3 Ubiquitin Ligases in Regulating the Growth, Development and Stress Response of Fruits and Vegetables [PDF]
Shipin KexueProtein ubiquitination, an important post-translational modification, plays a wide role in the life activities of eukaryotic cells. E3 ubiquitin ligases specifically recognize target proteins in the ubiquitin-proteasome degradation system and play a ...
DING Jun, LI Fujun, LI Xiao’an, ZHANG Xinhua
doaj +1 more source
How to Inactivate Human Ubiquitin E3 Ligases by Mutation
Frontiers in Cell and Developmental Biology, 2020 E3 ubiquitin ligases are the ultimate enzymes involved in the transfer of ubiquitin to substrate proteins, a process that determines the fate of the modified protein.
Cristina Garcia-Barcena +4 more
doaj +1 more source
Replication of proto-RNAs sustained by ligase-helicase cycle in oligomer world [PDF]
arXiv, 2013 A mechanism of the replication of proto-RNAs in oligomer world is proposed. The replication is carried out by a minimum cycle which is sustained by a ligase and a helicase. We expect that such a cycle actually worked in the primordial soup and can be constructed in vitro.
arxiv
Does inter-organellar proteostasis impact yeast quality and performance during beer fermentation? [PDF]
, 2019 During beer production, yeast generate ethanol that is exported to the extracellular environment where it accumulates. Depending on the initial carbohydrate concentration in the wort a high concentration of ethanol can be achieved in beer, often higher than 20% (v/v). It is noteworthy that the effects of elevated ethanol concentrations generated during
arxiv +1 more source