Results 51 to 60 of about 19,802 (121)
PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling [PDF]
arXiv, 2023 Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity strategies, such as PROTACs and molecular glues, have thus gained attention as pharmacological alternatives, but still require small molecule docking at binding pockets for targeted protein ...
arxiv
Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2012 Core histone proteins are essential for packaging the genomic DNA into chromatin in all eukaryotes. Since multiple genes encode these histone proteins, there is potential for generating more histones than what is required for chromatin assembly.
Rakesh Kumar Singh +3 more
doaj +1 more source
Novel RING E3 Ubiquitin Ligases in Breast Cancer
Neoplasia: An International Journal for Oncology Research, 2006 Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human diseases, including cancer, because of their central role in the control of diverse signaling pathways.
Angelika Burger +3 more
doaj +1 more source
Optimal experimental design in an EGFR signaling and down-regulation model [PDF]
arXiv, 2006 We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho ...
arxiv
Deciding Whether a Regular Language is Generated by a Splicing System [PDF]
arXiv, 2011 Splicing as a binary word/language operation is inspired by the DNA recombination under the action of restriction enzymes and ligases, and was first introduced by Tom Head in 1987. Shortly thereafter, it was proven that the languages generated by (finite) splicing systems form a proper subclass of the class of regular languages.
arxiv
Role and therapeutic potential of E3s in the tumor microenvironment of hepatocellular carcinoma
Frontiers in ImmunologyHepatocellular carcinoma (HCC) is a high-incidence, poor-prognosis malignancy worldwide, requiring new strategies for treatment. Ubiquitination, especially ubiquitination through E3 ubiquitin ligases, plays an indispensable role in the development and ...
Hailin Wang +10 more
doaj +1 more source
Splicing Systems from Past to Future: Old and New Challenges [PDF]
arXiv, 2015 A splicing system is a formal model of a recombinant behaviour of sets of double stranded DNA molecules when acted on by restriction enzymes and ligase. In this survey we will concentrate on a specific behaviour of a type of splicing systems, introduced by P\u{a}un and subsequently developed by many researchers in both linear and circular case of ...
arxiv
Modeling PROTAC Degradation Activity with Machine Learning [PDF]
Artificial Intelligence in the Life Sciences, Volume 6, 2024,
100104PROTACs are a promising therapeutic modality that harnesses the cell's built-in degradation machinery to degrade specific proteins. Despite their potential, developing new PROTACs is challenging and requires significant domain expertise, time, and cost. Meanwhile, machine learning has transformed drug design and development.
arxiv +1 more source
F1000Research, 2020 Protein ubiquitylation is essential for the maintenance of cellular homeostasis. E3 ubiquitin ligases are key components of the enzymatic machinery catalyzing the attachment of ubiquitin to substrate proteins. Consequently, enzymatic dysfunction has been
Vishnu Balaji, Thorsten Hoppe
doaj +1 more source
Frontiers in Cell and Developmental BiologyUbiquitination is a crucial post-translational modification of proteins that mediates the degradation or functional regulation of specific proteins. This process participates in various biological processes such as cell growth, development, and signal ...
Heng-Rui Zhang +10 more
doaj +1 more source