Results 291 to 300 of about 718,207 (427)

Butelase-mediated cyclization and ligation of peptides and proteins

open access: yesNature Protocols, 2016
G. K. T. Nguyen   +5 more
semanticscholar   +1 more source

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

open access: yesAdvanced Science, EarlyView.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman   +11 more
wiley   +1 more source

Resection vs. Ligation vs. Preservation of the Thoracic Duct During Esophagectomy for Cancer: A Systematic Review and Meta-Analysis. [PDF]

open access: yesCancers (Basel)
Nijssen DJ   +7 more
europepmc   +1 more source

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

open access: yesAdvanced Science, EarlyView.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou   +11 more
wiley   +1 more source

M2 Macrophage‐Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1hi Neutrophils to Enhance Inflamed Bone Regeneration

open access: yesAdvanced Science, EarlyView.
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao   +7 more
wiley   +1 more source

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

open access: yesAdvanced Science, EarlyView.
The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang   +9 more
wiley   +1 more source

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