Results 311 to 320 of about 740,839 (401)

tRF‐5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, EarlyView.
Acute respiratory distress syndrome (ARDS) is a severe lung condition with limited treatments, often triggered by overactive endothelial cells (ECs). It is identified that macrophage‐derived secretory autophagosomes (MSAPs) exacerbate lung damage by activating EC function.
Xing‐xing Zhu   +17 more
wiley   +1 more source

Gastroprotective and Antioxidant Properties of Linalyl Acetate in Ethanol-Induced Gastric Ulcer in Rats. [PDF]

open access: yesAdv Biomed Res
Navvabi Z   +6 more
europepmc   +1 more source

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

open access: yesAdvanced Science, EarlyView.
DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai   +8 more
wiley   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

open access: yesAdvanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai   +9 more
wiley   +1 more source

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

open access: yesAdvanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia   +39 more
wiley   +1 more source

Exploring the Non-Toxic Therapeutic Potential of <i>Dioscorea communis</i> in Combating Oral Pathogenic Bacteria and Their Effects on Hard and Soft Oral Tissues. [PDF]

open access: yesBiomedicines
Papantonaki AI   +7 more
europepmc   +1 more source

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