Results 321 to 330 of about 740,839 (401)

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Proximal ligation of the pulmonary vein stump to prevent postoperative cerebral infarction after a lobectomy†. [PDF]

Eur J Cardiothorac Surg
Nishimura T, Okada S, Kameyama K, Honda K, Nakazono C, Tokuda R, Ishihara S, Teramukai S, Inoue M, Ueshima Y.   +9 more
europepmc   +1 more source

Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1

Advanced Science, EarlyView.
Through elaborate design, a biodegradable scaffold with excellent mechanical properties and suitability is fabricated, providing spatial support for subsequent physiological activities. The prepared GA‐HBC‐LIC hydrogel possesses sequential antibacterial, antioxidant, anti‐inflammatory and immunomodulatory functions, offering a suitable chemical and ...
Jiafei Chen, Xiaoxu Guan, Lina Chen, Bingzhu Zheng, Feiyu Li, Chao Fang, Yike Fu, Xiang Li, Huiming Wang, Yi Zhou   +9 more
wiley   +1 more source

Nanoscale Metal‐Organic Framework‐Based Self‐Monitoring Oxygen Economizer and ROS Amplifier for Enhanced Radiotherapy‐Radiodynamic Therapy

Advanced Science, EarlyView.
A Fe (III)–Pt (II) porphyrin framework‐based radiosensitizer (FPTM‐LP) is constructed to serve as an oxygen economizer, hypoxia self‐monitoring device, and reactive oxygen species (ROS) amplifier. The glutathione (GSH)/pH‐responsive release of lonidamine achieves oxygen‐economization to combat hypoxia‐induced radioresistance guided by near infrared ...
Shiye Du, Qiang Wen, Ting Han, Jiongyu Ren, Mingyu Wang, Yunpeng Dai, Xiaoguang Ge, Lu Li, Junzhi Liu, Shi Gao   +9 more
wiley   +1 more source

Comparative Study of Click Handle Stability in Common Ligation Conditions. [PDF]

Bioconjug Chem
Fawcett C, Watson J, Richards S, Doherty AE, Seki H, Love EA, Coles CH, Coe DM, Jamieson C.   +8 more
europepmc   +1 more source

Sterilization, Infecundity, and Reproductive Autonomy in Rural, Suburban, and Urban America: Results From a National Survey. [PDF]

Perspect Sex Reprod Health
Clark S, Levy Z.
europepmc   +1 more source

Application of ⁶⁸Ga- and ¹⁷⁷Lu-Labeled FAP Inhibitor in Evaluation and Treatment of Cardiac Fibrosis After Myocardial Infarction. [PDF]

MedComm (2020)
Zhao Y, Su X, Xiang B, Zhang S, Zhou X.
europepmc   +1 more source

Statistical analysis of repertoire data demonstrates the influence of microhomology in V(D)J recombination. [PDF]

Nucleic Acids Res
Russell ML, Trofimov A, Bradley P, Matsen Iv FA.   +3 more
europepmc   +1 more source