Results 61 to 70 of about 740,839 (401)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Immobilization of Staphylococcus aureus Sortase A on Chitosan Particles and Its Applications in Peptide-to-Peptide Ligation and Peptide Cyclization

Molecules, 2018
Chitosan macro-particles prepared by the neutralization method were applied to Sortase A (SrtA) immobilization using glutaraldehyde as a crosslinking agent.
Min Yang, Haofei Hong, Shaozhong Liu, Xinrui Zhao, Zhimeng Wu   +4 more
doaj   +1 more source

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. [PDF]

, 2018
Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor.
Grandis, Jennifer R, Ha, Patrick K, Johnson, Daniel E, Lee, David S, Lee, David S, O'Keefe, Rachel A   +5 more
core   +2 more sources

Effects of Arteriovenous Fistula Ligation on Cardiac Structure and Function in Kidney Transplant Recipients.

Circulation, 2019
BACKGROUND Cardiovascular morbidity and mortality remain high in recipients of a kidney transplant. The persistence of a patent arteriovenous fistula (AVF) after transplantation may contribute to ongoing maladaptive cardiovascular remodeling. The ability
Nitesh N. Rao, Nitesh N. Rao, M. Stokes, A. Rajwani, S. Ullah, K. Williams, D. King, Ewan Macaulay, C. Russell, S. Olakkengil, R. Carroll, R. Faull, K. Teo, S. McDonald, M. Worthley, P. Coates   +15 more
semanticscholar   +1 more source

Advances in Proline Ligation [PDF]

Journal of the American Chemical Society, 2012
Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer.
Suwei Dong, Steven D. Townsend, Zhongping Tan, Samuel J. Danishefsky, Samuel J. Danishefsky, John A. Brailsford, Shiying Shang   +6 more
openaire   +3 more sources

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Twin reversed arterial perfusion sequence/syndrome - An insight into the ultrasonographic features for prenatal diagnosis and review of literature with obstetric importance: Case series of two reports

Indian Journal of Health Sciences and Biomedical Research KLEU, 2017
We present two case reports of twin reversed arterial perfusion sequence - a rare type of twin-twin transfusion syndrome, wherein there maldevelopment of one twin and is supplied by the normal twin.
Mohd Ilyas, Arshad Bhat
doaj   +1 more source

Lung Injury Pathways: Adenosine Receptor 2B Signaling Limits Development of Ischemic Bronchiolitis Obliterans Organizing Pneumonia [PDF]

, 2017
Purpose/Aim of the Study: Adenosine signaling was studied in bronchiolitis obliterans organizing pneumonia (BOOP) resulting from unilateral lung ischemia. Materials and Methods: Ischemia was achieved by either left main pulmonary artery or complete hilar
Auchampach, John, Audi, Said H., Densmore, John C., Dwinell, Melinda R., Geurts, Aron M., Jacobs, Elizabeth R., Jeziorczak, Paul M., Medhora, Meetha, Nayak, Shraddha, Schaid, Terry R.   +9 more
core   +1 more source

Labeling of Unique Sequences in Double-Stranded DNA at Sites of Vicinal Nicks Generated by Nicking Endonucleases [PDF]

, 2008
We describe a new approach for labeling of unique sequences within dsDNA under nondenaturing conditions. The method is based on the site-specific formation of vicinal nicks, which are created by nicking endonucleases (NEases) at specified DNA sites on ...
Frank-Kamenetskii, Maxim D., Kuhn, Heiko
core   +3 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source