Results 81 to 90 of about 88,762 (345)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Study of protein-bacteriochlorophyll and protein-lipid interactions of natural and model light-harvesting complex 2 in purple bacterium Rhodobacter sphaeroides. [PDF]

, 2007
The natural design of the photosystems of plants and photosynthetic bacteria using chlorophylls (Chls) or bacteriochlorophylls (BChls) as photoreceptors are robust.
Kwa, Lee Gyan
core  

The C‐Terminal Domain of Light‐Harvesting Chlorophyll‐a/b‐Binding Protein is Involved in the Stabilisation of Trimeric Light‐Harvesting Complex [PDF]

European Journal of Biochemistry, 1996
Light‐harvesting chlorophyll a/b‐binding protein (LHCP) can be reconstituted with pigments in detergent solution to yield stable monomeric light‐harvesting chlorophyll a/b complex (LHCII). This reconstitution is not significantly affected when up to ten amino acids are deleted on the C‐terminus of LHCP or when a tryptophan, which is 11 positions from ...
A, Kuttkat, A, Hartmann, S, Hobe, H, Paulsen   +3 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Characterization of a trimeric light-harvesting complex in the diatom Phaeodactylum tricornutum built of FcpA and FcpE proteins

, 2010
Fucoxanthin chlorophyll proteins (Fcps), the light-harvesting antennas of heterokont algae, are encoded by a multigene family and are highly similar with respect to their molecular masses as well as to their pigmentation, making it difficult to purify ...
Kroth, Peter G., Schmidt, Matthias, Büchel, Claudia, Weisheit, Wolfram, Joshi-Deo, Jidnyasa, Mittag, Maria, Gruber, Ansgar   +6 more
core   +1 more source

Exploring the structure of the N-terminal domain of CP29 with ultrafast fluorescence spectroscopy [PDF]

, 2009
A high-throughput Förster resonance energy transfer (FRET) study was performed on the approximately 100 amino acids long N-terminal domain of the photosynthetic complex CP29 of higher plants. For this purpose, CP29 was singly mutated along its N-terminal
Koehorst, R.B.M., Rob B. M. Koehorst, van Amerongen, H., Berghuis, B., Laptenok, S., Hoek, A. van, Amerongen, H., van, Berghuis, B.A., Hoek, A., van, Ruud B. Spruijt, Arie van Hoek, van Hoek, A., van Oort, B.F.; id_orcid, Oort, B.F. van, Sergey P. Laptenok, Spruijt, R.B., Bojk A. Berghuis, Bart van Oort, van Oort, B.F., Amerongen, H. van, Oort, B.F., van, Herbert van Amerongen   +21 more
core   +1 more source

Fast Diffusion of the Unassembled PetC1-GFP Protein in the Cyanobacterial Thylakoid Membrane

Life, 2020
Biological membranes were originally described as a fluid mosaic with uniform distribution of proteins and lipids. Later, heterogeneous membrane areas were found in many membrane systems including cyanobacterial thylakoids.
Radek Kaňa, Gábor Steinbach, Roman Sobotka, György Vámosi, Josef Komenda   +4 more
doaj   +1 more source

Light-Harvesting Chlorophyll a/b-Binding Protein Inserted into Isolated Thylakoids Binds Pigments and Is Assembled into Trimeric Light-Harvesting Complex [PDF]

Plant Physiology, 1995
The light-harvesting chlorophyll a/b-binding protein (LHCP) is largely protected against protease (except for about 1 kD on the N terminus) in the thylakoid membrane; this protease resistance is often used to assay successful insertion of LHCP into isolated thylakoids in vitro.
A, Kuttkat, R, Grimm, H, Paulsen
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Linear dichroism and circular dichroism in photosynthesis research [PDF]

, 2009
The efficiency of photosynthetic light energy conversion depends largely on the molecular architecture of the photosynthetic membranes. Linear- and circular-dichroism (LD and CD) studies have contributed significantly to our knowledge of the molecular ...
van Amerongen, H., Győző Garab, Amerongen, H., van, Garab, G., Herbert van Amerongen   +4 more
core   +1 more source