Results 51 to 60 of about 621 (173)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

DETERMINATION OF THE ISSUE CONCERNING THE LIFT RESISTANCE FACTOR OF LIGHTWEIGHT CAR

Nauka ta progres transportu, 2015
Purpose. The analytical study of the connection between the longitudinal force, acting on the light-weight car, lateral and vertical forces of interaction in the contact zone «wheel – rail» with the lift resistance factor value is to provide a simple ...
A. O. Shvets, К. I. Zhelieznov, А. S. Аkulov, О. M. Zabolotnyi, Ye. V. Chabaniuk   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Identifying the Secondary Jet in the RadioAstron Image of OJ 287

The Astrophysical Journal
The 136 yr long optical light curve of OJ 287 is explained by a binary black hole model where the secondary is in a 12 yr orbit around the primary. Impacts of the secondary on the accretion disk of the primary generate a series of optical flares that ...
Mauri J. Valtonen, Lankeswar Dey, Staszek Zola, Alok C. Gupta, Shubham Kishore, Achamveedu Gopakumar, Paul J. Wiita, Minfeng Gu, Kari Nilsson, Zhongli Zhang, Rene Hudec, Katsura Matsumoto, Marek Drozdz, Waldemar Ogloza, Andrei V. Berdyugin, Daniel E. Reichart, Markus Mugrauer, Tapio Pursimo, Stefano Ciprini, Tatsuya Nakaoka, Makoto Uemura, Ryo Imazawa, Michal Zejmo, Vladimir V. Kouprianov, James W. Davidson Jr., Alberto Sadun, Jan Štrobl, Martin Jelínek, Abhimanyu Susobhanan   +28 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of operation and emission characteristics of refrigerated-vehicles based on remote technology

Heliyon
Remote online monitoring technology is an effective method for tracking in-use diesel vehicles. Based on remote data from the OBD system, this study compares and analyzes the operation characteristic, emissions and fuel consumption of light-, medium ...
Xionghui Zou, Yanyan Yang, Zhengjun Yang, Jingyuan Li, Yu Liu, Yang Lu, Qian Feng   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

An onsite demonstration and validation of LiDAR technology for wind energy resource assessment

International Journal of Sustainable Energy, 2019
The investigation of wind resource at higher heights is very crucial in planning wind power project. Normally, this involves the installation of a high and costly meteorological mast with a cup anemometer and wind vanes.
Prem Kumar Chaurasiya, Vilas Warudkar, Siraj Ahmed   +2 more
doaj   +1 more source