Results 61 to 70 of about 621 (173)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

High speed biaxial piezoelectric MEMS micromirror with varifocal tunability

Microsystems & Nanoengineering
High-speed control of light in 3D space is a rapidly advancing field because it enables unique applications in neurobiology, communications, laser micromachining, and augmented/virtual reality.
Hunter Shillingburg, Daniel Lopez
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Benefit Impact of Air Pollution Reduction Through ATCS Implementation at Intersections

E3S Web of Conferences, 2018
The field study in five intersections that had ATCS, such as Krapyak, Tugu Muda, Polda, Bangkong and Fatmawati were done to investigate the effectivity of air pollution reduction. The study was done by estimating the differences between the vehicle speed
Arief Budihardjo Mochamad, Setiyo Huboyo Haryono, Prasetyo Samadikun Budi   +2 more
doaj   +1 more source

Experimental Planting and Monitoring to Develop Restoration Strategy for the Endangered Epiphytic Orchid, [PDF]

Geo Data
This study reported an experimental re-introduction of the endangered epiphytic orchid species, Phalaenopsis japonica. The three experimental sites were established in Hongdo Natural Reserve in Jeollanam-do, South Korea, each of which differed in ...
Seongjun Kim, Chang Woo Lee, Hwan Joon Park, Jung Eun Hwang, Young-Joong Kim, Hyeong Bin Park, Yubin Lee   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Compromise-free scaling of qubit speed and coherence

Nature Communications
Across leading qubit platforms, a common trade-off persists: increasing coherence comes at the cost of operational speed, reflecting the notion that protecting a qubit from its noisy surroundings also limits control over it.
Miguel J. Carballido, Simon Svab, Rafael S. Eggli, Taras Patlatiuk, Pierre Chevalier Kwon, Jonas Schuff, Rahel M. Kaiser, Leon C. Camenzind, Ang Li, Natalia Ares, Erik P. A. M. Bakkers, Stefano Bosco, J. Carlos Egues, Daniel Loss, Dominik M. Zumbühl   +14 more
doaj   +1 more source

Enhanced Performance of a High-Speed WDM CAP64 VLC System Employing Volterra Series-Based Nonlinear Equalizer

IEEE Photonics Journal, 2015
The light-emitting diode nonlinearity in visible light communication (VLC) systems is considered to be a major problem that deteriorates system performance.
Yiguang Wang, Li Tao, Xingxing Huang, Jianyang Shi, Nan Chi   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Synergetic action of light and temperature on seed germination of some solanaceae members [PDF]

Journal of Stress Physiology & Biochemistry, 2013
The objective of the present study was to evaluate the effects of nine combinations of temperature and light on seeds germination of four solanaceae species (Datura innoxia, Hyoscyamus muticus, Solanum nigrum and Withania ...
Nasser A.M. Barakat, H.F. Kabeil, A.K. Hegazy, Nesrine S. Singer   +3 more
doaj