Results 41 to 50 of about 3,775,582 (265)
Constructivisme et pédagogie dans l’enseignement de la natation
eJournal de la Recherche sur l'Intervention en Éducation Physique et Sport, 2012 Cette contribution souhaite faire le point sur la possible contribution du constructivisme au renouvellement d’une pédagogie de la natation. Si les pédagogies orientées par le constructivisme ont profondément renouvelé les manières d’appréhender l ...
Richard Light, Yannick Lémonie
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Liinc em Revista, 2017 RESUMO Em outubro de 2915, organizamos uma oficina para 80 pesquisadores e praticantes envolvidos em makerspaces na Europa. Nosso objetivo era explorar como os makerspaces podem fomentar desenvolvimento sustentável.
Adrian Smith, Ann Light
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Открытое образование (Москва), 2016 One-to-one educational model of mobile learning at school is essential part of Innovative education reform and modernization of Russian educational system [1].
Daniel Light, Elizabeth Pierson
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Verso il cielo: la Comunicazione Mediata da Computer a supporto dei corsi universitari tradizionali
Italian Journal of Educational Technology, 1997 Riflessioni sull’uso della posta elettronica come strumento di discussione e di apprendimento per studenti universitari in campus.
Christofer Colbourn, Paul Light
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source