Results 41 to 50 of about 13,240,817 (334)
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Interpreting and Implementing the Long Term Athlete Development Model: English Swimming Coaches’ Views on the (Swimming) LTAD in Practice [PDF]
, 2010 The LTAD (Long Term Athlete Development) model has come to represent a sports-wide set of principles that significantly influences national sports policy in England.
Lang, M, Light, R
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Troubling futures: can participatory design research provide a generative anthropology for the 21st century? [PDF]
, 2015 This essay argues there is value in considering participatory design as a form of generative anthropology at a time when we recognise that we need not only to understand cultures but to change them towards sustainable living.
Light, Ann
core
Identification of a Non-Pentapeptide Region Associated with Rapid Mycobacterial Evolution. [PDF]
PLoS ONE, 2016 A large portion of the coding capacity of Mycobacterium tuberculosis is devoted to the production of proteins containing several copies of the pentapeptide-2 repeat, namely the PE/PPE_MPTR proteins.
Per Warholm, Sara Light
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Alienation and Stress among Doctors: Dilemmas and Possible Solutions
Professions and Professionalism, 2015 Studies of alienation, stress, burnout, and dissatisfaction among doctors are plagued by unclear and varied definition of these terms. Many are small, local, and short, which limit insights.
Donald W. Light
doaj +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
, 2018 The regulator that designs and first implements a federal regulatory program does not always have the ability to control the timing and process of how that regulatory program will, in this Symposium’s language, “exit.” As the 2016 election has ...
Light, Sarah E.
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Nature, 1873 Reprinted 1895. ; Series title also at head of t.-p. ; Mode of access: Internet.
openaire +9 more sources