Results 41 to 50 of about 3,893,782 (263)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Constructivisme et pédagogie dans l’enseignement de la natation

open access: yeseJournal de la Recherche sur l'Intervention en Éducation Physique et Sport, 2012
Cette contribution souhaite faire le point sur la possible contribution du constructivisme au renouvellement d’une pédagogie de la natation. Si les pédagogies orientées par le constructivisme ont profondément renouvelé les manières d’appréhender l ...
Richard Light, Yannick Lémonie
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

TO LIGHT. [PDF]

open access: yesAnglia - Zeitschrift für englische Philologie, 1897
n ...
openaire   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Cultivating sustainable developments with makerspaces | Cultivando desenvolvimento sustentável com espaços maker

open access: yesLiinc em Revista, 2017
RESUMO Em outubro de 2915, organizamos uma oficina para 80 pesquisadores e praticantes envolvidos em makerspaces na Europa. Nosso objetivo era explorar como os makerspaces podem fomentar desenvolvimento sustentável.
Adrian Smith, Ann Light
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

HIGHLIGHTING CHANGES IN TWO RUSSIAN SCHOOLS WITH SUCCESSFUL ONE-TO-ONE LAPTOP PROGRAMS: MOSCOW AND NIZHNY NOVGOROD CASE STUDIES

open access: yesОткрытое образование (Москва), 2016
One-to-one educational model of mobile learning at school is essential part of Innovative education reform and modernization of Russian educational system [1].
Daniel Light, Elizabeth Pierson
doaj   +1 more source

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