Results 51 to 60 of about 13,730,156 (351)
FEBS Letters, EarlyView.Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley +1 more source
Scientific Reports, 2022 Implementing effective antimicrobial therapy close to the onset of infection lowers morbidity and mortality and attenuates the spread of antimicrobial resistance.
Larry Burg +13 more
doaj +1 more source
FEBS Letters, EarlyView.Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki +4 more
wiley +1 more source
Alienation and Stress among Doctors: Dilemmas and Possible Solutions
Professions and Professionalism, 2015 Studies of alienation, stress, burnout, and dissatisfaction among doctors are plagued by unclear and varied definition of these terms. Many are small, local, and short, which limit insights.
Donald W. Light
doaj +1 more source
Social networking and digital gaming media convergence : classification and its consequences for appropriation [PDF]
, 2008 Within the field of Information Systems, a good proportion of research is concerned with the work organisation and this has, to some extent, restricted the kind of application areas given consideration. Yet, it is clear that information and communication
Griffiths, M, Light, BA
core +3 more sources
Nature, 1873 Reprinted 1895. ; Series title also at head of t.-p. ; Mode of access: Internet.
openaire +9 more sources
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
Risky business: when a CRM vendor masqueraded as an ERP specialist [PDF]
, 2007 Taking a social shaping perspective we unpack the development trajectory of a packaged software product to show, that contrary to mainstream accounts, design is not completely specified a-priori and that the process continues throughout implementation,
Griffiths, M, Light, BA
core +1 more source
Light Triggers the Search for Light [PDF]
Plant Physiology, 2019 Plants rely on light for photosynthesis. As a consequence, plant growth is strongly shaped by light availability, to optimize photon absorbance in the green tissues. Seedlings that germinated underground grow quickly to escape from the darkness, while plants that are threatened to be overgrown ...
openaire +4 more sources
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source