Results 51 to 60 of about 17,219,574 (393)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Engaging Students and Faculty in the Evaluation of a USMLE Review Product: Implications for Library Collection Development [PDF]

open access: yes, 2016
Introduction: Study materials for USMLE exams are some of the most commonly requested materials at Dana Medical Library. In Fall 2015, the Dana Medical Library received several student requests for online USMLE preparation materials.
Light, Jeanene, Stokes, Alice
core   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Light Sources and Lighting Circuits

open access: yesJournal of Light & Visual Environment, 2008
According to machinery statistics of the Ministry of Economy, Trade and Industry, the quantity of electric lamps produced in Japan was 613,000,000 (68.1% compared to the previous year). Of these, 73,000,000 were general lamps (88.1% compared to the previous year) and 32,000,000 were halogen lamps (79.3% compared to the previous year).
Takeo Yasuda   +7 more
openaire   +6 more sources

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Brokering between heads and hearts: an analysis of designing for social change [PDF]

open access: yes, 2009
This paper describes a fluid and responsive design process identified among certain practitioners involved in solving social problems or inspiring social change.
Light, Ann, Miskelly, C.
core  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Rapid pathogen identification and phenotypic antimicrobial susceptibility directly from urine specimens

open access: yesScientific Reports, 2022
Implementing effective antimicrobial therapy close to the onset of infection lowers morbidity and mortality and attenuates the spread of antimicrobial resistance.
Larry Burg   +13 more
doaj   +1 more source

Risky business: when a CRM vendor masqueraded as an ERP specialist [PDF]

open access: yes, 2007
Taking a social shaping perspective we unpack the development trajectory of a packaged software product to show, that contrary to mainstream accounts, design is not completely specified a-priori and that the process continues throughout implementation,
Griffiths, M, Light, BA
core   +1 more source

Libri-Light: A Benchmark for ASR with Limited or No Supervision [PDF]

open access: yesIEEE International Conference on Acoustics, Speech, and Signal Processing, 2019
We introduce a new collection of spoken English audio suitable for training speech recognition systems under limited or no supervision. It is derived from open-source audio books from the LibriVox project.
Jacob Kahn   +14 more
semanticscholar   +1 more source

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