Results 51 to 60 of about 4,545,693 (268)

Sharing Economy vs Sharing Cultures? Designing for social, economic and environmental good [PDF]

open access: yesInteraction Design and Architecture(s), 2015
This paper explores the story behind a crowdfunding service as an example of sharing technology. Research in a small neighborhood of London showed how locally-developed initiatives can differ in tone, scale, ambition and practice to those getting ...
Ann Light, Clodagh Miskelly
doaj  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Reconfiguring Socialist Urban Landscapes: The ‘Left-Over’ Spaces of State-Socialism in Bucharest [PDF]

open access: yesHuman Geographies: Journal of Studies and Research in Human Geography, 2010
The end of state-socialism has produced complex processes of urban change in East and Central Europe including the reshaping of urban identities and urban cultural landscapes in post-socialist cities.
Duncan Light , Craig Young
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

HIGHLIGHTING CHANGES IN TWO RUSSIAN SCHOOLS WITH SUCCESSFUL ONE-TO-ONE LAPTOP PROGRAMS: MOSCOW AND NIZHNY NOVGOROD CASE STUDIES

open access: yesОткрытое образование (Москва), 2016
One-to-one educational model of mobile learning at school is essential part of Innovative education reform and modernization of Russian educational system [1].
Daniel Light, Elizabeth Pierson
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Evidence for a heritable predisposition to Chronic Fatigue Syndrome

open access: yesBMC Neurology, 2011
Background Chronic Fatigue Syndrome (CFS) came to attention in the 1980s, but initial investigations did not find organic causes. Now decades later, the etiology of CFS has yet to be understood, and the role of genetic predisposition in CFS remains ...
Bateman Lucinda   +4 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Finding a Future for Environmental Ethics [PDF]

open access: yesLes Ateliers de l’Ethique, 2012
Andrew Light
doaj   +1 more source

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