Results 191 to 200 of about 33,909 (239)

A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils. [PDF]

Nat Commun
Martinez-Rivas G, Ayala MV, Bender S, Codo GR, Swiderska WK, Lampis A, Pedroza L, Merdanovic M, Sicard P, Pinault E, Richard L, Lavatelli F, Giorgetti S, Canetti D, Rinsant A, Kaaki S, Ory C, Oblet C, Pollet J, Naser E, Carpinteiro A, Roussel M, Javaugue V, Jaccard A, Bonaud A, Delpy L, Ehrmann M, Bridoux F, Sirac C.   +28 more
europepmc   +1 more source

[Immunoglobulin light-chain type amyloidosis].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1995
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Light-chain cardiac amyloidosis

Current Problems in Cancer, 2017
Cardiac amyloidosis is an underrecognized condition, in which delays to diagnosis have great implications on management options, prognosis, and morbidity. Once cardiac tissue is infiltrated by amyloid fibrils, there is a cascade of pathologic changes that can display an array of clinical manifestations, from impaired relaxation of the ventricular ...
Anit K, Mankad, Isata, Sesay, Keyur B, Shah   +2 more
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Immunoglobulin light chain amyloidosis

Expert Review of Hematology, 2013
Primary light chain amyloidosis is the most common form of systemic amyloidosis and is caused by misfolded light chains that cause proteotoxicity and rapid decline of vital organ function. Early diagnosis is essential in order to deliver effective therapy and prevent irreversible organ damage.
MERLINI, GIAMPAOLO, Comenzo RL, Seldin DC, Wechalekar A, Gertz MA   +4 more
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[Light chain amyloidosis].

Innere Medizin (Heidelberg, Germany), 2023
Light chain amyloidosis (AL) is a rare protein deposition disease. It is caused by a clonal plasma cell or B‑cell disease in the bone marrow. With the exception of the central nervous system, all organs can be affected by amyloid deposits. Cardiac involvement is the most frequent organ manifestation that leads to significantly increased mortality when ...
Ute, Hegenbart, Fabian, Aus dem Siepen, Stefan, Schönland   +2 more
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Amyloidosis and Light Chain Plasmocytoma

Tumori Journal, 1976
Nine cases of light chain plasmocytomas, 6 type λ and 3 type k, have been studied in reference to amyloid presence and localisation. Bone marrow plasmocytosis, light chains in serum and/or in the urine, and osteolytic lesions were demonstrated in all the patients.
G, Tosato, E, Fagiolo
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Coagulation Abnormalities in Light Chain Amyloidosis

Mayo Clinic Proceedings, 2021
To assess the prevalence of coagulation abnormalities in patients with systemic light chain (AL) amyloidosis and their association with disease-related characteristics, disease progression, and survival.This is a retrospective study of patients with AL amyloidosis seen at Mayo Clinic, Rochester, Minnesota, from January 1, 2006, to December 31, 2015. We
Nadine Abdallah, Eli Muchtar, Angela Dispenzieri, Wilson Gonsalves, Francis Buadi, Martha Q. Lacy, Suzanne R. Hayman, Taxiarchis Kourelis, Prashant Kapoor, Ronald S. Go, Rahma Warsame, Nelson Leung, S. Vincent Rajkumar, Robert A. Kyle, Rajiv K. Pruthi, Morie A. Gertz, Shaji K. Kumar   +16 more
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Macroglossia in Light-Chain Amyloidosis

New England Journal of Medicine, 2018
Macroglossia in Light-Chain Amyloidosis A 78-year-old man presented with enlargement and stiffening of the tongue. Biopsy confirmed that this finding of macroglossia was due to light-chain amyloidosis.
João Melo Alves, Natália Marto
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Immunoglobulin Light Chain Systemic Amyloidosis

2016
Immunoglobulin light chain amyloidosis (AL) is a rare, complex disease caused by misfolded free light chains produced by a usually small, indolent plasma cell clone. Effective treatments exist that can alter the natural history, provided that they are started before irreversible organ damage has occurred.
Angela, Dispenzieri, Giampaolo, Merlini
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Light Chain Amyloidosis

2016
Light-chain (AL) amyloidosis is the most common cause of acquired systemic amyloidosis. It is a highly heterogeneous disease with a wide spectrum of clinical presentation. Prognosis of AL amyloidosis depends on organ, particularly cardiac, involvement.
Amara S. Hussain, Anita D’Souza
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