Results 81 to 90 of about 295,332 (287)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Optical Simulation and Optimization of Light Extraction Efficiency for Organic Light Emitting Diodes [PDF]
, 2016 : Current organic light emitting diodes (OLEDs) suffer from the low light extraction efficiency. In this thesis, novel OLED structures including photonic crystal, Fabry-Perot resonance cavity and hyperbolic metamaterials were numerically simulated and ...
core
A high-efficiency red light-emitting module utilizing PLCC packaging for plant lighting applications
Frontiers in PhysicsWith the increasing adoption of LEDs in plant lighting applications, reducing costs and enhancing light efficiency have emerged as key research priorities in this domain.
Limin Hu +6 more
doaj +1 more source
IEEE Photonics Journal, 2016 The effects of 2-D hexagonal-lattice TiO 2 photonic crystal layers on the directional light extraction efficiency of low-scattering (Y 1-xCe x) 3Al 5O 12 (YAG:Ce 3+) ceramic converters have been investigated.
Haiding Sun +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2016 Due to the large refractive index of ZnO material, light extraction efficiency (LEE) of ZnO based light-emitting diode (LED) is limited by the total reflection.
Dan Zhang (51283) +4 more
core +1 more source
Optimization by a genetic algorithm of the light-extraction efficiency of a GaN light-emitting diode [PDF]
, 2015 Light extraction from light-emitting materials is fundamentally limited by internal reflections due to the high dielectric-constant contrast between the material that produces the light and the emergent medium.
Mayer, Alexandre, Bay, Annick
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source