Results 61 to 70 of about 1,606,955 (297)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Serial block-face scanning electron microscopy of adherent cells on thin plastic substrate

Methods in Microscopy
Serial block-face (SBF) scanning electron microscopy (SEM) is used for imaging the entire internal ultrastructure of cells, tissue samples or small organisms.
Kauter Anne, Bürge Silvio, Klotz Christian, Laue Michael   +3 more
doaj   +1 more source

A solid‐phase transfection platform for arrayed CRISPR screens

Molecular Systems Biology, 2019
Arrayed CRISPR‐based screens emerge as a powerful alternative to pooled screens making it possible to investigate a wide range of cellular phenotypes that are typically not amenable to pooled screens. Here, we describe a solid‐phase transfection platform
Özdemirhan Serçin, Sabine Reither, Paris Roidos, Nadja Ballin, Spyridon Palikyras, Anna Baginska, Katrin Rein, Maria Llamazares, Aliaksandr Halavatyi, Hauke Winter, Thomas Muley, Renata Z Jurkowska, Amir Abdollahi, Frank T Zenke, Beate Neumann, Balca R Mardin   +15 more
doaj   +1 more source

Uncovering Differently Expressed Markers and Heterogeneity on Human Pancreatic Cancer

Translational Oncology, 2020
Discovery of biomarkers is critical to understand tumor heterogeneity and microenvironment. To determine differently expressed makers on cancer tissue for comprehensive profiling, the multiplexed tissue imaging mass cytometer (IMC) which uniquely ...
Sorah Yoon, Haiqing Li, Loren Quintanar, Brian Armstrong, John J Rossi   +4 more
doaj   +1 more source

Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs

Virology Journal, 2022
Background Porcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs are transplanted to human recipients.
Sabrina Halecker, Ludwig Krabben, Yannick Kristiansen, Luise Krüger, Lars Möller, Dietmar Becher, Michael Laue, Benedikt Kaufer, Christian Reimer, Joachim Denner   +9 more
doaj   +1 more source

Hyperspectral darkfield microscopy of single hollow gold nanoparticles for biomedical applications [PDF]

, 2013
Hyperspectral microscopy is a versatile method for simultaneous spatial and spectroscopic characterization of nonfluorescent samples. Here we present a hyperspectral darkfield imaging system for spectral imaging of single nanoparticles over an area of ...
Acimovic, Agathi Christofidou, Alkilany, Ament, Anker, Antonios G. Kanaras, Arvizo, Barreto, Bartczak, Becker, Bingham, Brown, Dreaden, Erathodiyil, Grabinski, Hutter, Johnson, Jun, Krpetic, Lassiter, Michalet, Mock, Murray, Natasha Fairbairn, Otto L. Muskens, Parak, Rosman, Saha, Schwartzberg, Sonnichsen, Tracey A. Newman, Urban, Van Dijk, Wu, Xie, Zhang, Zhang, Zhao   +37 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Manufacturing and processing of sheets using a Mg–Al–Ca–Zn–Y alloy for automotive applications

Results in Engineering
As the transportation industry evolves, so do its needs, creating opportunities for the use of non-standard materials. While electrically powered vehicles (EVs) generally operate at lower temperatures than those with internal combustion engines ...
Stefan Gneiger, Nikolaus Papenberg, Stefan Mitsche, Martin Fehlbier   +3 more
doaj   +1 more source

Weak Measurements of Light Chirality with a Plasmonic Slit [PDF]

, 2012
We examine, both experimentally and theoretically, an interaction of tightly focused polarized light with a slit on a metal surface supporting plasmon-polariton modes.
B. Stein, C. Genet, E. Hasman, F. I. Fedorov, K. Y. Bliokh, K. Y. Bliokh, N. Shitrit, T. W. Ebbesen, V. Kleiner, Y. Gorodetski   +9 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source