Results 91 to 100 of about 450,897 (302)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

A customised method for estimating light transmission efficiency of the horizontal light pipe via a temporal parameter with an example application using laser-cut panels as a collector. [PDF]

MethodsX, 2021
Obradovic B, Matusiak B.
europepmc   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Analysis of Tensile Strenght and Shear Modulus of GRE Pipe using Ansys

Computational and Experimental Research in Materials and Renewable Energy, 2018
Composite materials (GRE pipe) had been applied in various industries. These kind application are based on the advantages of composite properties, that are lightweight, high corrosion resistance and low cost.
Dita Puspita, Siti Lailatul Arofah, Elok Hidayah, Lutfi Rohman, Ratna Dewi Syarifah   +4 more
doaj   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Experimental investigation of buried flexible HDPE pipe [PDF]

Građevinski Materijali i Konstrukcije
Buried pipes are used mainly for water supply and drainage, among many other applications such as oil, liquefied natural gas, coal slurries, and mine tailings.
Ratnaraju Rajkumar
doaj   +1 more source

Solar energy collection system [PDF]

, 1979
A fixed, linear, ground-based primary reflector having an extended curved sawtooth-contoured surface covered with a metalized polymeric reflecting material, reflects solar energy to a movably supported collector that is kept at the concentrated line ...
Miller, C. G., Stephens, J. B.
core   +1 more source

A new dielectric effect in viscous liquids

, 2013
An accurate experimental and theoretical study has been performed about a phenomenon, not previously reported in the literature, occurring in highly viscous liquids: the formation of a definite pipe structure induced by the passage of a heavy body, this ...
Capano, V., Esposito, S., Salesi, G.
core   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Fully recoverable retaining technology of sheet piles anchored by steel pipe piles for excavations and model tests

Yantu gongcheng xuebao
In light of the issues such as inefficiency of retaining component utilization, environmental contamination and excessive carbon emissions associated with excavation engineering, a fully recoverable retaining technology of sheet piles anchored by steel ...
LI Peng 1, 2, 3, LIU Qiang 4, YANG Junjie 2, 5, WU Gang 1, 3
doaj   +1 more source