Results 51 to 60 of about 1,408,386 (261)
Frontiers in Cell and Developmental BiologyThis article comprehensively reviews the complex role of the Notch signaling cascade in cancer, as well as the regulatory mechanisms and potential anti-cancer effects of food functional ingredients on this pathway.
Rong-Zu Nie +35 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FoodsPit mud (PM), as an important source of microorganisms, is necessary for Chinese strong-flavor baijiu (CSFB) production. Although it has been revealed that the PM prokaryotic community diversities are influenced by its quality, product area, ages, etc ...
Mingdong Deng +6 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Microstructure evolution of Al8.79Zn2.16Mg2.11Cu0.12Zr alloy during homogenization
Cailiao gongchengThe microstructure evolution in Al8.79Zn2.16Mg2.11Cu0.12Zr alloy ingot during the one-step low-temperature homogenization and three-steps high-temperature homogenization is investigated by the scanning electron microscopy （SEM）， differential scanning ...
ZHUANG Dayong +5 more
doaj +1 more source
Functionalized Nanomaterials Promote Rapid Analysis of New Contaminants in Foods: from Design to Application [PDF]
Shipin KexueIn recent years, the exposure risk of emerging contaminants in the food chain has become increasingly prominent. Although conventional analytical techniques are sensitive and accurate, they remain limited in complex matrices with low detection efficiency,
WEI Qing, LIU Yan, LIU Huilin
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Data-Driven Prediction Methods for Lithium-Ion Battery State of Health Based on Elbow Rule
IEEE AccessLithium-ion batteries are extensively utilized in diverse sectors such as automotive applications. The imprecise estimation of the State Of Health (SOH) will significantly impact safe operations and cost reduction initiatives.
Liu Zhang +6 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source