Results 91 to 100 of about 5,326,889 (255)
Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden+15 more
wiley +1 more source
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi+4 more
wiley +1 more source
Light scattering in donor lenses
Light scattering for normal and cataractous lenses from 21-86 yr old donors was measured in vitro. As expected, scattering increased with severity of cataract. Scattering decreased with angle according to a power law. This corresponded to the power law finding for functional straylight measurements in early-cataract patients using white light (power ...
J. K. Ijspeert, T. J. T. P. Van Den Berg
openaire +3 more sources
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso+5 more
wiley +1 more source
The study presents an efficient simulation approach for the polymer laser powder bed fusion process polymers process, validated with polyamide 12, polyamide 6, and polyetherketoneketone. It shows that inter layer time affects part density, with 90s yielding dense parts.
Claas Bierwisch+4 more
wiley +1 more source
Additive manufacturing of magnesium alloys by laser is difficult because the melting point of the oxide layer is much higher than the evaporation temperature of the metal underneath. Making the oxide layer thinner can solve this problem. Alloying magnesium with strontium makes the oxide layer thinner, especially at 0.5 wt%.
Elmar Jonas Breitbach+8 more
wiley +1 more source
Light-by-light scattering in SANC
In this paper we describe the implementation of the QED process $ \to $ through a fermion loop into the framework of SANC system. The computations of this process takes into account non-zero mass of loop-fermion. We briefly describe additional precomputation modules used for calculation of massive fermion-box diagrams.
Bardin, D.+3 more
openaire +2 more sources
From Damage to Functionality: Remanufacturing of Thrust Roller Bearings by Tailored Forming
Herein, the wear and fatigue behavior of repaired bearing raceways with a new powder alloy is investigated using a FE8 test‐rig and an oscillating tribometer. The tests are compared with industrial manufactured bearings to evaluate the repair quality. The repair can extend the service life of the repaired bearing to that of a new bearing and improves ...
Felix Saure+3 more
wiley +1 more source
This study explores a process chain to produce dispersoid‐strengthened CuCr1Zr for applications requiring high strength and conductivity. Using gas‐atomized powder and copper‐plated alumina nanoparticles, additive manufacturing is performed via powder bed based additive manufacturing with green and red lasers, followed by heat treatment.
Heinrich von Lintel+7 more
wiley +1 more source
Hybrid materials enable high‐performance components but are challenging to process. This study explores an inductive heating concept with spray cooling for steel–aluminum specimens in a two‐step process including friction welding and cup backward extrusion.
Armin Piwek+7 more
wiley +1 more source