Results 211 to 220 of about 4,134,739 (261)
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
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FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
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Shining a light on rhodopsin signaling
Science Signaling, 2022Monitoring rhodopsin signaling in real time reveals the role of native lipids in modulating GPCR interactions.
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Light signal transduction in plants
Trends in Cell Biology, 1997Light signal-transduction pathways are a central component of the mechanisms that regulate plant development. These pathways provide the means by which information from specific wavelengths of light may be amplified and coordinated, resulting in complex physiological and developmental responses.
S A, Barnes, R B, McGrath, N H, Chua
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Light Signal Transduction in Plants
Photochemistry and Photobiology, 1996Plants, as sessile organisms, have developed intricate signal transduction networks used to adapt to the changing environment surrounding them. One of the most important dynamic environmental factors is light, and the light control of dicotyledonous seedling development is one of the best studied examples.
J M, Staub, X W, Deng
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Integration of light and plastid signals
Current Opinion in Plant Biology, 2008Light and plastid signals promote chloroplast biogenesis and are among the most potent inducers and repressors of photosynthesis-related gene expression, respectively. These signals can be likened to a 'gas and brake system' that promotes efficient chloroplast biogenesis and function.
Robert M, Larkin, Michael E, Ruckle
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Phytochrome and Light Signaling in Marchantia
2019Bryophytes, which comprise liverworts, mosses, and hornworts, are one of the earliest diverging lineages of extant land plants and a key plant group for understanding evolutionary aspects of land plant adaptation. Marchantia polymorpha, a liverwort, has recently been established as a model plant species having molecular genetic tractability.
Keisuke, Inoue +2 more
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Phototropin and light-signaling in phototropism
Current Opinion in Plant Biology, 2006Blue-light-induced phototropism in higher plants is regulated by phototropin, which is a photoreceptor kinase that contains a flavin mononucleotide (FMN). Recently, it was found that this kinase is inhibited by the binding of the LOV2 (light-oxygen-voltage2) domain in the dark but that its activity is increased in the light by the release of the LOV2 ...
Mitsuhiro, Kimura, Takatoshi, Kagawa
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Dissecting signaling at the speed of light
Nature Methods, 2011Researchers use light-activated photo-uncaging to dissect the elementary steps in protein kinase signaling networks in living human cells.
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Shining a light on cell signaling
Science, 2017Protein Design Protein kinases are proteins that are used to transmit signals within cells. Zhou et al. engineered diverse kinases so that they could be switched on and off with visible light. They modified the fluorescent protein Dronpa so that instead of being tetrameric, it dimerized in violet light and dissociated in cyan light, and they fused two ...
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