Results 91 to 100 of about 12,438,760 (311)

The linac coherent light source single particle imaging road map

Structural Dynamics, 2015
Intense femtosecond x-ray pulses from free-electron laser sources allow the imaging of individual particles in a single shot. Early experiments at the Linac Coherent Light Source (LCLS) have led to rapid progress in the field and, so far, coherent ...
A. Aquila, A. Barty, C. Bostedt, S. Boutet, G. Carini, D. DePonte, P. Drell, S. Doniach, K. Downing, T. Earnest, H. Elmlund, V. Elser, M. Gühr, J. Hajdu, J. Hastings, S. Hau-Riege, Z. Huang, E. Lattman, F. Maia, S. Marchesini, A. Ourmazd, C. Pellegrini, R. Santra, I. Schlichting, C. Schroer, J. Spence, I. Vartanyants, S. Wakatsuki, W. Weis, G. Williams   +29 more
semanticscholar   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The Coherent X-ray Imaging instrument at the Linac Coherent Light Source

Journal of Synchrotron Radiation, 2015
Description of the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source. Recent scientific highlights illustrate the femtosecond crystallography, high power density and extreme matter capabilities of the CXI instrument.
M. Liang, Garth J. Williams, M. Messerschmidt, M. Seibert, P. Montanez, M. Hayes, D. Milathianaki, A. Aquila, Mark S. Hunter, J. Koglin, D. Schafer, S. Guillet, A. Busse, R. Bergan, William Olson, Kay Fox, Nathaniel Stewart, Robin Curtis, A. Miahnahri, S. Boutet   +19 more
semanticscholar   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Cows, Pigs and People: Enhanced Intensity-Based Clustering of Isomorphous Multi- Crystal Datasets in the Presence of Subtle Variations [PDF]

Structural Dynamics
The high-throughput data collection capabilities of modern X-ray facilities are challenging data processing pipelines to keep pace, while also remaining accessible to non-expert users.
Amy J Thompson, James Beilsten-Edmands, Cicely Tam, Juan Sanchez-Weatherby, James Sandy, Halina Mikolajek, Danny Axford, Sofia Jaho, Michael A Hough, Graeme Winter   +9 more
doaj   +1 more source

The Advanced Light Source

IEEE Transactions on Nuclear Science, 1983
The Advanced Light Source (ALS) is a new synchrotron radiation source which has been proposed by Lawrence Berkeley Laboratory. The ALS will be a key component in a major new research facility, the National Center for Advanced Materials. The ALS will consist of an electron linear accelerator, a "booster" synchrotron, a 1.3-GeV electron storage ring, and
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The X-ray Pump–Probe instrument at the Linac Coherent Light Source

Journal of Synchrotron Radiation, 2015
A description of the X-ray Pump–Probe (XPP) instrument at the Linac Coherent Light Source. is presented. Recent scientific highlights illustrate the versatility and the time-resolved X-ray diffraction and spectroscopy capabilities of the XPP instrument.
M. Chollet, R. Alonso-Mori, M. Cammarata, D. Damiani, J. Defever, J. Delor, Yiping Feng, J. Glownia, J. Langton, S. Nelson, Kelley Ramsey, A. Robert, M. Sikorski, Sanghoon Song, D. Stefanescu, V. Srinivasan, D. Zhu, H. Lemke, D. Fritz   +18 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

High-efficiency multilayer grating for enhanced tender x-ray photoelectron spectroscopy

Scientific Reports
X-ray Photoelectron Spectroscopy (XPS) is a powerful tool for probing the chemical and electronic states of materials with elemental specificity and surface sensitivity.
Wai Jue Tan, Arindam Majhi, Wadwan Singhapong, Andrew C. Walters, Matthijs A. van Spronsen, Georg Held, Burcu Karagoz, David C. Grinter, Pilar Ferrer, Guru Venkat, Qiushi Huang, Zhe Zhang, Zhanshan Wang, Patrick Yuheng Wang, Andrey Sokolov, Hongchang Wang, Kawal Sawhney   +16 more
doaj   +1 more source