Results 81 to 90 of about 12,438,760 (311)

Limited-angle x-ray nano-tomography with machine-learning enabled iterative reconstruction engine

npj Computational Materials
A long-standing challenge in tomography is the ‘missing wedge’ problem, which arises when the acquisition of projection images within a certain angular range is restricted due to geometrical constraints.
Chonghang Zhao, Mingyuan Ge, Xiaogang Yang, Yong S. Chu, Hanfei Yan   +4 more
doaj   +1 more source

Determination of Angle of Refraction in X-Ray Phase-Contrast Imaging Using Geometric Optics Method

Photonics
The accurate calculation of the angle of refraction of X-rays passing through an object is essential in X-ray phase-contrast imaging. While the wave optics-based method is commonly employed to calculate the angle of refraction, it presents several ...
Jun Yang, Fangke Zong, Haoqi Tang, Yang Du, Rongchang Chen   +4 more
doaj   +1 more source

Holographic free-electron light source

Nature Communications, 2016
Recent advances in the physics and technology of light generation via free-electron proximity and impact interactions with nanostructures (gratings, photonic crystals, nano-undulators, metamaterials and antenna arrays) have enabled the development of ...
Guanhai Li, B. Clarke, J. So, K. Macdonald, N. Zheludev   +4 more
semanticscholar   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Climbing Mountains: Building a Data Capture and Correction System for JUNGFRAU 9M [PDF]

Structural Dynamics
The JUNGFRAU detector is a charge integrating, high-frame-rate, imaging detector developed by the PSI detector group, originally to support the SwissFEL Aramis beamline.
Graeme Winter, Nick E Devenish, James O'Hea, Gary Yendell   +3 more
doaj   +1 more source

The mesoSPIM initiative – open-source light-sheet microscopes for imaging cleared tissue

Nature Methods, 2019
Light-sheet microscopy is an ideal technique for imaging large cleared samples; however, the community is still lacking instruments capable of producing volumetric images of centimeter-sized cleared samples with near-isotropic resolution within minutes ...
F. Voigt, Daniel Kirschenbaum, Evgenia Platonova, S. Pagès, Robert A. A. Campbell, Rahel Kastli, Martina Schaettin, Ladan Egolf, Alexander van der Bourg, P. Bethge, Karen Haenraets, N. Frezel, T. Topilko, P. Perin, D. Hillier, Sven Hildebrand, Anna Schueth, A. Roebroeck, B. Roska, E. Stoeckli, R. Pizzala, N. Renier, H. Zeilhofer, T. Karayannis, U. Ziegler, L. Batti, A. Holtmaat, C. Lüscher, A. Aguzzi, F. Helmchen   +29 more
semanticscholar   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Diamond Light Source

Science Progress, 2015
This Current Commentary was prompted by a recent talk given by Laura Holland, at Reading Skeptics in the Pub, about the Diamond Light Source, where she is the Outreach and Events Manager. Skeptics in the Pub (1) is a growing, informal network of (usually) monthly meetings, where the invited speaker presents a topic of interest in a pub, which is ...
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source