Results 141 to 150 of about 7,175,761 (309)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Integrating Solar Induced Fluorescence and the Photochemical Reflectance Index for Estimating Gross Primary Production in a Cornfield

Remote Sensing, 2013
The utilization of remotely sensed observations for light use efficiency (LUE) and tower-based gross primary production (GPP) estimates was studied in a USDA cornfield.
Yen-Ben Cheng, Elizabeth M. Middleton, Qingyuan Zhang, Karl F. Huemmrich, Petya K. E. Campbell, Lawrence A. Corp, Bruce D. Cook, William P. Kustas, Craig S. Daughtry   +8 more
doaj   +1 more source

The potential for photosynthesis in hydrothermal vents: a new avenue for life in the Universe?

, 2013
We perform a quantitative assessment for the potential for photosynthesis in hydrothermal vents in the deep ocean. The photosynthetically active radiation in this case is from geothermal origin: the infrared thermal radiation emitted by hot water, at ...
Cardenas, Rolando, Leiva-Mora, Michel, Martin, Osmel, Perez, Noel   +3 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Effects of the Temporal Aggregation and Meteorological Conditions on the Parameter Robustness of OCO-2 SIF-Based and LUE-Based GPP Models for Croplands

Remote Sensing, 2019
Global retrieval of solar-induced chlorophyll fluorescence (SIF) using remote sensing by means of satellites has been developed rapidly in recent years.
Xiaofeng Lin, Baozhang Chen, Huifang Zhang, Fei Wang, Jing Chen, Lifeng Guo, Yawen Kong   +6 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Efficient light transport using precomputed visibility

, 2001
Visibility computations are the most time-consuming part of globalillumination algorithms. The cost is amplified by the fact thatquite often identical or similar information is recomputed multipletimes. In particular this is the case when multiple images of thesame scene are to be generated under varying lighting conditionsand/or viewpoints.
Daubert, K., Heinrich, W., Kautz, J., Dischler, J., Seidel, H. ; https://orcid.org/0000-0002-1343-8613   +4 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Application timing and duration of LED and HPS supplements differentially influence yield, nutrient bioaccumulation, and light use efficiency of greenhouse basil across seasons. [PDF]

Front Plant Sci, 2023
Hammock HA, Kopsell DA, Sams CE.
europepmc   +1 more source

Linewidth characteristics of Raman-shifted dye laser output at 720 and 940 nm [PDF]

, 1986
Existing DIAL systems for water vapor measurements in the troposphere operate at wavelengths near 720 nm. The use of stronger water vapor absorption lines in the range 930 to 960 nm will significantly improve DIAL measurements in the upper troposphere ...
Grossmann, B. E., Higdon, N. S., Higdon, N. S., Higdon, N. S., Higdon, N. S., Higdon, N. S., Higdon, N. S.   +6 more
core   +1 more source