Results 31 to 40 of about 1,300,705 (268)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Defeating strength-plasticity trade-off of Al–Zn–Mg–Cu alloy by spray forming and double step extrusion

Journal of Materials Research and Technology
A well strength-plasticity balance is necessary for industry application of high Zn 7xxx series alloys. Herein, we proposed a combination process of spray forming rapid solidification plus extrusion processes (i.e., single forward extrusion (FE alloy ...
Kaiyun Xiang, Lulu Pan, Guoqing Xu, Lipeng Ding, Zhihong Jia   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Microstructure and Mechanical Properties of Ultrafine-Grained Dual-Phase 0.1C3Mn Steel Processed by Warm Deformation

Metals
In this study, we have explored the thermomechanical processing on 0.1C3Mn steel to produce an ultrafine-grained (UFG) dual-phase (DP) microstructure. The composition was designed to allow a decrease in temperature for the warm deformation of austenite ...
Yongkang Wang, Chenglu Liu, Qingquan Lai
doaj   +1 more source

Towards the understanding of fracture resistance of an ultrahigh-strength martensitic press-hardened steel

Journal of Materials Research and Technology, 2023
Identifying the fracture resistance capabilities and gaining a deeper understanding of the controlling damage mechanisms are important to the development of press-hardened steels (PHS) for automotive applications.
Qingquan Lai, Zixuan Chen, Yuntao Wei, Qi Lu, Yi Ma, Jianfeng Wang, Guohua Fan   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effect of Al–5Ti–1B grain refiner on the microstructure, mechanical properties and acoustic emission characteristics of Al5052 aluminium alloy

Journal of Materials Research and Technology, 2015
In the present investigation, the effect of Al–5Ti–1B grain refiner on the microstructure, mechanical properties and acoustic emission characteristics of Al 5052 aluminium alloy have been studied. Microstructural analysis showed the presence of primary α
Amulya Bihari Pattnaik, Satyabrat Das, Bharat Bhushan Jha, Nedumbilly Prasanth   +3 more
doaj   +1 more source

Stress-dependent subsurface structural transformations of gradient nanograin Ti–6Al–4V alloy and its impact on wear behavior

Journal of Materials Research and Technology, 2023
Gradient nanograin (GNG) metals possess outstanding resistance to sliding friction and wear. The tribolayer plays a major role in the wear performance of metals. However, the current understanding of the tribolayer in GNG metals is still limited.
Chenglin Wang, Yonggang Zhang, Haitao Zhang, Jiyu Liu, Zhonggang Sun, Xuesong Fu, Wenlong Zhou, Lipeng Ding, Zhihong Jia   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Crack inhibition and crystallographic texture control in an additively manufactured IN738LC Ni-based superalloy

Journal of Materials Research and Technology
The additive manufacturing of directionally solidified Ni-based superalloys remains a significant challenge due to the formation of stray equiaxed grains and their high susceptibility to cracking, particularly for high-volume γ´-type Ni-based superalloys.
Fangxian Zhang, Liping Zhou, Xinliang Xie, Zhenbo Zhang, Qi Chao, Guohua Fan   +5 more
doaj   +1 more source