Results 71 to 80 of about 1,300,705 (268)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Triethylamine-Capped Calcium Phosphate Oligomers/Polyacrylamide Synergistically Reinforced α-Hemihydrate Gypsum Composites: A Mechanistic Study on Mechanical Strengthening via Organic/Inorganic Interpenetrating Networks

Molecules
In this study, a novel calcium phosphate/polyacrylamide copolymer/α-type hemihydrate gypsum (CPO/PAM/α-HHG) composite material was prepared by polymerising a stable inorganic CPO precursor, end-capped with triethylamine (TEA), with an organic ...
Yuan Chen, Li Chen, Hao Li, Bin Zhang, Marie-Christine Record, Pascal Boulet, Juan Wang, Jan-Michael Albina, Yi Yang, Weiliang Ma   +9 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Multi‐Step Deposition Strategy for β‐SiC Coatings on Cf/C Composites: Achieving Breakthrough Oxidation Resistance and Mechanical Properties

Advanced Science
Current SiC coating technologies for anti‐oxidation Cf/C composites, such as pack cementation, often rely on high‐temperature in situ reaction with severe mechanical property decay.
Dou Hu, Bing Liu, Xiaoxuan Li, Jia Sun, Tao Li, Yang Xu, Hejun Li, Qiangang Fu   +7 more
doaj   +1 more source

Quasi-in-situ investigation on recrystallization behavior of an Al–Mg-Sc-Zr alloy under different homogenization processes

Journal of Materials Research and Technology
The influence of different homogenization treatments on the recrystallization behavior of Al–Mg-Sc-Zr alloys during annealing was examined using scanning electron microscopy, transmission electron microscopy and quasi-in-situ electron backscatter ...
Yi Su, Lipeng Ding, Yu Zhang, Chenglin Wang, Yaoyao Weng, Linzhong Zhuang, Zhihong Jia   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Functionally Graded Oxide Scale on (Hf,Zr,Ti)B2 Coating with Exceptional Ablation Resistance Induced by Unique Ti Dissolving

Advanced Science
Multicomponent Ti‐containing ultra‐high temperature ceramics (UHTCs) have emerged as more promising ablation‐resistant materials than typical UHTCs for applications above 2000 °C. However, the underlying mechanism of Ti improving the ablation performance
Junshuai Lv, Wei Li, Yanqin Fu, Menglin Zhang, Lingxiang Guo, Fanyu Lu, Jiachen Li, Tao Li, Yulei Zhang, Hejun Li   +9 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Achieving the synergistic of strength and ductility in Mg-15Gd-1Zn-0.4Zr alloy with hierarchical structure

Journal of Magnesium and Alloys
Currently, the hierarchical structure is one of the most effective means to enhance the strength and plasticity of metal materials, since the strain localization can be effectively delayed by the coordination of the unique microstructure.
Kun Jiang, Minghang Zhou, Haoxin Wu, Senzhong Liu, Yujuan Wu, Yong Liu   +5 more
doaj   +1 more source

Light-Weight MPC

, 2023
Modell-prediktiv regulering har vorte eit viktig verktøy i moderne industri. Mykje på grunn av dugleiken til å optimalt styre avanserte system. Ved å ta prediksjonar og systembegrensingar i betraktning kan styringslova heve grad av sikkerheit og pålitelegheit for industrielle operasjonar.
openaire   +1 more source