Results 191 to 200 of about 783,623 (305)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cobalt-Catalyzed Highly Regioselective Alkoxycarbonylation of Olefins Driven by Light. [PDF]

J Am Chem Soc
Peng Y, Tian X, Cao Z, Vuong TH, Steinfeldt N, Zhang B, Jiao H, Junge H, Beller M.   +8 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

LED Light-Quality Optimization to Enhance Shoot and Essential Oil Yield of <i>Tagetes erecta</i> L. in Controlled Environment. [PDF]

Molecules
Chu HTT, Nguyen NH, Phan Q, Dinh TTT, Hoang THT, Nguyen TV, Chu HH, Tong QC, Tien TQ, Setzer WN, Tran KQ, Do PT.   +11 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Evaluating LED parameters in a growth chamber to maintain potato yield and enhance minitubers production in greenhouse with molecular insights. [PDF]

Sci Rep
Li J, Li Y, Yu C, Lin HH, Liu T, Zhang F, Wang D, Raza W, Zhang L, Kear P, Shi Y, Xu C, Guo X, Hein I, Feng Y.   +14 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Agronomic and Physiological Aspects of Programmed Cycle Pruning in <i>Coffea arabica</i>. [PDF]

Plants (Basel)
Baitelle DC, Freitas SJ, Vieira HD, Verdin Filho AC, Berilli SDS, Freitas ILJ, Rodrigues WP, Baroni DF, Freitas SP, Miranda GB, Arndt S, Tavares OCH, Dalvi LP, Santos PCD.   +13 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Influence of Shading on Essential Oil Quantity and Quality of Sage (<i>Salvia officinalis</i> L.) at Different Harvest Times. [PDF]

Plants (Basel)
Milenković L, Ilić ZS, Stanojević L, Šunić L, Milenković A, Tmušić N, Lalević D, Stanojević J, Cvetković D, Kevrešan Ž.   +9 more
europepmc   +1 more source