Results 1 to 10 of about 1,301,037 (308)

Alkyl derivative of p-terphenyl as an activator of the plastic scintillators with n/γ-discrimination ability [PDF]

Ядерна фізика та енергетика, 2023
In order to increase the solubility of p-terphenyl molecules, their structure was modified with tert-butyl groups. A derivative of p-terphenyl 2,4,4′-tris-tert-butyl-1,1′:4′,1′-terphenyl was obtained.
D. A. Yelisieiev, O. V. Yelisieieva, Yu. О. Нurkalenko, P. М. Zhmurin, V. D. Alekseev   +4 more
doaj   +1 more source

Modeling Regulation of Zinc Uptake via ZIP Transporters in Yeast and Plant Roots [PDF]

, 2012
In yeast (Saccharomyces cerevisiae) and plant roots (Arabidopsis thaliana) zinc enters the cells via influx transporters of the ZIP family. Since zinc is both essential for cell function and toxic at high concentrations, tight regulation is essential for
Chavarría-Krauser, Andrés, Claus, Juliane   +1 more
core   +11 more sources

Sirtuin Modulators in Cellular and Animal Models of Human Diseases

Frontiers in Pharmacology, 2021
Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell ...
Jun Young Hong, Hening Lin, Hening Lin
doaj   +1 more source

The Double-Edged Sword of SIRT3 in Cancer and Its Therapeutic Applications

Frontiers in Pharmacology, 2022
Reprogramming of cellular energy metabolism is considered an emerging feature of cancer. Mitochondrial metabolism plays a crucial role in cancer cell proliferation, survival, and metastasis.
Shumin Ouyang, Qiyi Zhang, Linlin Lou, Kai Zhu, Zeyu Li, Peiqing Liu, Xiaolei Zhang   +6 more
doaj   +1 more source

Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

Frontiers in Pharmacology, 2021
Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding.
Yanan Liu, Yanan Liu, Canwei Wang, Jifa Li, Jiandong Zhu, Chengguang Zhao, Chengguang Zhao, Huanhai Xu   +7 more
doaj   +1 more source

The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance

Frontiers in Oncology, 2022
Sirtuin 3 (SIRT3), the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, acts as a metabolic modulator mainly located in mitochondria via regulating the process of the relevant biochemical processes by targeting crucial mediators. Recently,
QingYi Zhao, Jing Zhou, Feng Li, Sen Guo, Liang Zhang, Jing Li, Qin Qi, Qin Qi, Yin Shi, Yin Shi   +9 more
doaj   +1 more source

Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies

Biomolecules, 2020
To study the structure and function of the pH-regulated receptor tyrosine kinase insulin receptor-related receptor (IRR), а member of the insulin receptor family, we obtained six mouse monoclonal antibodies against the recombinant IRR ectodomain.
Alexander S. Goryashchenko, Andrey A. Mozhaev, Oxana V. Serova, Tatiana N. Erokhina, Alexander N. Orsa, Igor E. Deyev, Alexander G. Petrenko   +6 more
doaj   +1 more source

A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate

Molecules, 2022
SIRT1, an NAD+-dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD+ into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr).
Nian-Da Yu, Bing Wang, Xin-Zhu Li, Hao-Zhen Han, Dongxiang Liu   +4 more
doaj   +1 more source

Efficiency comparison of mixture formulations in the stabilisation/solidification of the loess silt contaminated with zinc in terms of mechanical properties

Budownictwo i Architektura, 2023
The effectiveness of various types of binders in stabilizing/solidifying (S/S) contaminated soils is strongly dependent on the type of soil and contaminants present.
Agnieszka Lal, Joanna Fronczyk, Małgorzata Franus   +2 more
doaj   +1 more source

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model. [PDF]

, 2020
Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo.
Chang, Deching, Chang, Hao-Fang, Chen, Bing-Mao, Chen, Shih-Han, Chen, Thomas C, Collins, Sara, Kasahara, Noriyuki, Lin, Sheng-Che, Lu, Yin-Che, Sun, Jui-Ming, Tai, Chien-Kuo, Wang, Hsin-Ell, Wang, Weijun, Wu, Shu-Fen   +13 more
core   +2 more sources