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Alkyl derivative of p-terphenyl as an activator of the plastic scintillators with n/γ-discrimination ability [PDF]
Ядерна фізика та енергетика, 2023 In order to increase the solubility of p-terphenyl molecules, their structure was modified with tert-butyl groups. A derivative of p-terphenyl 2,4,4′-tris-tert-butyl-1,1′:4′,1′-terphenyl was obtained.
D. A. Yelisieiev +4 more
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Activated: Decentering activism in and with academia [PDF]
Companion Publication of the 2021 Conference on Computer Supported Cooperative Work and Social Computing, 2021 Who is an activist? With the advent of activism-related scholarship in HCI and CSCW, the current challenge involves thinking about what activism is, who an activist is, and the opportunities and limitations of activism. Recently, researchers in academia and industry, such as Timnit Gebru, demonstrate a commitment to stay activated for the structural ...
Minha Lee +4 more
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Sirtuin Modulators in Cellular and Animal Models of Human Diseases
Frontiers in Pharmacology, 2021 Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell ...
Jun Young Hong, Hening Lin, Hening Lin
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The Double-Edged Sword of SIRT3 in Cancer and Its Therapeutic Applications
Frontiers in Pharmacology, 2022 Reprogramming of cellular energy metabolism is considered an emerging feature of cancer. Mitochondrial metabolism plays a crucial role in cancer cell proliferation, survival, and metastasis.
Shumin Ouyang +6 more
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To Activate or Not to Activate [PDF]
Circulation Research, 2013 In a recent study, Watanabe et al identify a novel enhancer in the fgf10 locus that is necessary and sufficient for expression in anterior second heart field. Their results suggest a competitive mechanism in which Isl1 and Nkx2-5 bind the enhancer to activate or repress this enhancer, respectively.
Cornelis J, Boogerd, Sylvia M, Evans
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Activate or Not: Learning Customized Activation [PDF]
2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2021 We present a simple, effective, and general activation function we term ACON which learns to activate the neurons or not. Interestingly, we find Swish, the recent popular NAS-searched activation, can be interpreted as a smooth approximation to ReLU. Intuitively, in the same way, we approximate the more general Maxout family to our novel ACON family ...
Ningning Ma +3 more
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Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
Frontiers in Pharmacology, 2021 Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding.
Yanan Liu +7 more
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Frontiers in Oncology, 2022 Sirtuin 3 (SIRT3), the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, acts as a metabolic modulator mainly located in mitochondria via regulating the process of the relevant biochemical processes by targeting crucial mediators. Recently,
QingYi Zhao +9 more
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Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies
Biomolecules, 2020 To study the structure and function of the pH-regulated receptor tyrosine kinase insulin receptor-related receptor (IRR), а member of the insulin receptor family, we obtained six mouse monoclonal antibodies against the recombinant IRR ectodomain.
Alexander S. Goryashchenko +6 more
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Molecules, 2022 SIRT1, an NAD+-dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD+ into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr).
Nian-Da Yu +4 more
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