Results 131 to 140 of about 87,316 (308)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
StreetlightSim: a simulation environment to evaluate networked and adaptive street lighting
Sustaining the operation of street lights incurs substantial financial and environmental cost. Consequently, adaptive lighting systems have been proposed incorporating ad-hoc networking, sensing, and data processing, in order to better manage the street ...
Merrett, Geoff V. +3 more
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Rethinking colored lighting in workplace environments
, 2020 Thesis: S.M., Massachusetts Institute of Technology, Department of Architecture, September, 2020Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, September, 2020Cataloged from student ...
Lesina Debiasi, Lukas.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Commercialization of QD WLED technology
, 2006 Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006.Includes bibliographical references.It is well known that the use of high-brightness LEDs for illumination has the potential to substitute ...
Zhao, Xinyue, M. Eng. Massachusetts Institute of Technology
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
, 2012 Without light, interior architecture cannot be fully designed and experienced. It is one of the key tools for an interior designer, but can be a dauntingly technical subject for students.
Innes, Malcolm
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Value proposition analysis for solid state lighting: A case study of Ahmedali Ahmed Electrical Contracting; Marketing the product in the Kingdom of Bahrain [PDF]
, 2010 The proposition given to a product or service in terms of its worth given by a customer is researched and analysed to find the underlying factors contributing to the value. The study is undertaken to investigate the different factors that lays ground for
Vinsend, Justin
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
IEEE Photonics JournalThis research investigates the light quality and thermal management of InGaN and InGaAlP Light Emitting Diodes (LEDs) under various light regulation methods.
Miroslav Slouka +3 more
doaj +1 more source