Results 51 to 60 of about 75,865 (305)

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Revisiting Lightning Activity and Parameterization Using Geostationary Satellite Observations

Remote Sensing, 2021
The Geostationary Lightning Mapper (GLM) on the Geostationary Operational Environmental Satellite 16 (GOES-16) detects total lightning continuously, with a high spatial resolution and detection efficiency.
Xin Zhang, Yan Yin, Julia Kukulies, Yang Li, Xiang Kuang, Chuan He, Jeff L. Lapierre, Dongxin Jiang, Jinghua Chen   +8 more
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Three-Dimensional Lightning Characteristics Analysis over the Tibetan Plateau Based on Satellite-Based and Ground-Based Multi-Source Data

Atmosphere
Based on the data from the Chinese national ground-based (LFEDA: Low-frequency E-field Detection Array) and satellite-based lightning-detection systems (LMI: Lightning Mapping Imager), the spatial and temporal distribution statistical properties of all ...
Jie Zhu, Shulin Zhi, Dong Zheng, Zhengguo Yuan   +3 more
doaj   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Inter-Comparison of Lightning Trends from Ground-Based Networks During Severe Weather: Applications Toward GLM [PDF]

, 2011
The planned GOES-R Geostationary Lightning Mapper (GLM) will provide total lightning data on the location and intensity of thunderstorms over a hemispheric spatial domain.
Bateman, Monte, Blakeslee, Richard J., Carey, Lawrence D., Cecil, Daniel J., Goodman, Steven J., Petersen, Walter A., Rudlosky, Scott D., Schultz, Chris J.   +7 more
core   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Atomic Scale Ordering of Liquid Water at a Dynamic Pt(111) Interface Under Electrochemical Conditions Imaged by Electron Holography

Advanced Energy Materials, EarlyView.
High resolution electron holography was used to image the projected electric potential of ordered water layers at the interface to a platinum (111) electrode. The observed reorganization of the water layers upon applying external potentials suggests that the electric potential drop of the electric double layer is mainly carried by the polarization ...
Jonas Lindner, Ulrich Ross, Tobias Meyer, Sung Sakong, Axel Gross, Michael Seibt, Christian Jooss   +6 more
wiley   +1 more source

Holes in Optical Lightning Flashes: Identifying Poorly Transmissive Clouds in Lightning Imager Data

Earth and Space Science, 2021
Space‐based optical lightning sensors including the lightning imaging sensor (LIS) and geostationary lightning mapper (GLM) are pixelated imagers that detect lightning as transient increases in cloud top illumination. Detection requires optical emissions
Michael Peterson
doaj   +1 more source

Truth‐telling in the Australian Curriculum

The Curriculum Journal, EarlyView.
Abstract Unlike Canada and South Africa, Australia has not completed a national Truth‐telling of First Nations histories. As a consequence, the curriculum is at risk of excluding Truth‐telling, leading to indoctrination of past injustices as part of school learning.
Glenn Auld, Aleryk Fricker, A. Bryan Fricker, Jessamy Gleeson, Genée Marks, Jo Raphael, Roy Rozario, Peta J. White, Brezshia Ashcroft, Robin A. Bellingham, Alessandra D'Arbe, Brianna Damcevski, Jennie Darcy, Kim Davies, Claudia Filipic, Brandi Fox, Paul Garner, Amanda Hall, Shelley Hannigan, Amrita Kamath, Katie Lee, Eun‐ju Lee, Jing Leong, Catherine Milvain, Jonathan Newchurch, Alistair Noble, Joanne O'Mara, Jacqui Peters, Monika Wagner, Yinfeng Wang   +29 more
wiley   +1 more source