Results 51 to 60 of about 133,552 (239)

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

COMPARISON TWO LOCATIONS OF LIGHTNING DETECTION

Jurnal Meteorologi Klimatologi dan Geofisika, 2019
The objective of this study was to identify the lightning distribution by comparing of two lightning sensors located in Jakarta and Bandung. Using Storm Tracker Lightning Detector maintained by the Indonesia Agency for Meteorology, Climatology and Geophysics (BMKG), Cloud-to-Ground lightning (CG) analyzed with a various radius i.e. 0.1˚, 0.5˚ and 1.0˚.
Riza Arian Noor, Anton Widodo, Hadi Suntoko, Deni Septiadi   +3 more
openaire   +2 more sources

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Lightning Occurrence between 2016 and 2020 in Fusagasugá, Cundinamarca, Colombia

Ingeniería
Context: Lightning is a powerful natural phenomenon that poses a risk to life and infrastructure, given the enormous amounts of energy it can transfer in short periods of time, especially in cloud-to-ground strikes.
Fernando Díaz-Ortiz, Neyder Perilla López, Juan Pablo Ospina Carrillo, Pedro Cifuentes Guerrero   +3 more
doaj   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Analysis of lightning localization errors based on different station layouts

暴雨灾害
To explore the influence of the lightning detection station layout on lightning location accuracy, the magnetic field waveform observation data from the natural lightning observation test base at Jiuxian Mountain in Fujian Province were used and ten ...
Yingting ZENG, Jiaying GU, Ruoyun ZHANG, Qinbo YANG, Jinquan ZENG   +4 more
doaj   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

A Fast and Fine‐Resolution Location Method for Lightning Channels Based on Time Series Segmented Feature of Low Frequency Signal

Earth and Space Science
Most real‐time lightning location systems are based on feature matching to locate lightning, but they often lack the ability to locate lightning channels.
Jingxuan Wang, Yang Zhang, Yanfeng Fan, Yijun Zhang, Dong Zheng, Weitao Lyu   +5 more
doaj   +1 more source

Upgraded Low-Frequency 3D Lightning Mapping System in North China and Observations on Lightning Initiation Processes

Remote Sensing
The three-dimensional (3D) low-frequency lightning mapping system (LF-LMS) in north China has been updated. The lightning electric field derivative (dE/dt) sensor and continuous acquisition mode has been newly designed to ensure a capability of entire ...
Mingyuan Liu, Xiushu Qie, Zhuling Sun, Rubin Jiang, Hongbo Zhang, Ruiling Chen, Shanfeng Yuan, Yu Wang, Xiangke Liu   +8 more
doaj   +1 more source

Inter-Comparison of Lightning Trends from Ground-Based Networks During Severe Weather: Applications Toward GLM [PDF]

, 2011
The planned GOES-R Geostationary Lightning Mapper (GLM) will provide total lightning data on the location and intensity of thunderstorms over a hemispheric spatial domain.
Bateman, Monte, Blakeslee, Richard J., Carey, Lawrence D., Cecil, Daniel J., Goodman, Steven J., Petersen, Walter A., Rudlosky, Scott D., Schultz, Chris J.   +7 more
core   +1 more source