Results 191 to 200 of about 749,250 (317)

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, Volume 16, Issue 2, Page 365-381, February 2026.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

Climatological hazard indicators for a robust and integrated energy infrastructure in Austria. [PDF]

open access: yesSci Data
Maier P   +7 more
europepmc   +1 more source

Designing Memristive Materials for Artificial Dynamic Intelligence

open access: yesAdvanced Intelligent Discovery, Volume 2, Issue 1, February 2026.
Key characteristics required of memristors for realizing next‐generation computing, along with modeling approaches employed to analyze their underlying mechanisms. These modeling techniques span from the atomic scale to the array scale and cover temporal scales ranging from picoseconds to microseconds. Hardware architectures inspired by neural networks
Youngmin Kim, Ho Won Jang
wiley   +1 more source

Characterization of lightning-induced overvoltages in wind farms. [PDF]

open access: yesPLoS One
Eliyan T   +3 more
europepmc   +1 more source

Burn Selection: How Fire Injury Shaped Human Evolution

open access: yesBioEssays, Volume 48, Issue 2, February 2026.
Intentional fire use exposed humans and their ancestors to high‐temperature burn injury, a risk rare in other species, bringing major survival benefits and technologies but also repeated exposure to extreme heat. The Burn Selection Hypothesis reframes this cost of fire mastery as a unique selective pressure, which shaped our evolution.
Joshua Cuddihy   +9 more
wiley   +1 more source

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