Results 151 to 160 of about 7,157 (269)

Optimising Haematopoietic Stem Cell Transplantation: Enhancing Myeloablation Sensitivity and Alleviating Anaemia Using Roxadustat (FG‐4592)

open access: yesCell Proliferation, EarlyView.
The use of FG‐4592 in the process of myeloablation can promote haematopoietic cell apoptosis for more effective myeloablation, maintain the number of RBC and may create a pluripotent microenvironment suitable for donor cells, so as to enable more effective haematopoietic reconstruction of donor cells in vivo.
Guanheng Yang   +8 more
wiley   +1 more source

Leadership and Accountability in Faith‐Based Institutions: Evidence From UK Mosques

open access: yesFinancial Accountability &Management, EarlyView.
ABSTRACT This study investigates accountability in religious institutions on the basis of evidence obtained from interviews with relevant parties in UK mosques. We mobilize prior theoretical contention regarding servant leadership and constraints on personal accountability to expose perceptions of seriously deficient discharge outcomes.
Umair Riaz   +3 more
wiley   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

open access: yesThe FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi   +8 more
wiley   +1 more source

Polarimetric radar characteristics of lightning initiation and propagating channels [PDF]

open access: yes
In this paper we present an analysis of a large dataset of lightning and polarimetric weather radar data collected in the course of a lightning measurement campaign that took place in the summer of 2017 in the area surrounding Säntis, in the northeastern
Van der Velde, Oscar Arnoud   +13 more
core  

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

open access: yesThe FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano   +10 more
wiley   +1 more source

LMA observations of upward lightning flashes at the Säntis Tower initiated by nearby lightning activity [PDF]

open access: yes
We present in this paper lightning current measurements, LMA (Lightning Mapping Array) data and fast antenna electric fields associated with upward flashes observed at the Säntis Tower during summer of 2017.
Pineda, Nicolau   +14 more
core  

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

open access: yesThe FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb   +4 more
wiley   +1 more source

Spatial proteomic mapping of the human and mouse retina using IBEX. [PDF]

open access: yesJCI Insight
Meng Y   +10 more
europepmc   +2 more sources

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