Results 191 to 200 of about 57,668 (300)

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, Volume 16, Issue 2, Page 365-381, February 2026.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

What is innovation? [PDF]

Heart Rhythm O2
Ghanbari H.
europepmc   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

Contemporary Fire Regimes of the Subtropical Everglades. [PDF]

Sci Data
Malone SL, McLeod G, Chen A, Tupaj M.
europepmc   +1 more source

Designing Memristive Materials for Artificial Dynamic Intelligence

Advanced Intelligent Discovery, Volume 2, Issue 1, February 2026.
Key characteristics required of memristors for realizing next‐generation computing, along with modeling approaches employed to analyze their underlying mechanisms. These modeling techniques span from the atomic scale to the array scale and cover temporal scales ranging from picoseconds to microseconds. Hardware architectures inspired by neural networks
Youngmin Kim, Ho Won Jang
wiley   +1 more source

UKEV forum 2024: The UK Society for Extracellular Vesicle annual meeting - bridging innovation and impact. [PDF]

Extracell Vesicles Circ Nucl Acids
Jackson HK, Akbar N, Peake N, Pink RC, Lawson C.   +4 more
europepmc   +1 more source

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell, Joshua A. Kulas, William E. Carter, June Javens‐Wolfe, Raven Dance Hinkel, Mustapha Moussaif, Jacob S. Smiley, Olivia Lazaro, Sylvia Robertson, Alan D. Palkowitz, Bruce T. Lamb, Timothy I. Richardson, Jeffrey L. Dage, Shaoyou Chu, Travis Johnson, Louis F. Stancato, Abdul Qadir Syed   +16 more
wiley   +1 more source

Quantifying CO₂ forcing effects on lightning, wildfires, and climate interactions. [PDF]

Sci Adv
Verjans V, Franzke CLE, Lee SS, Kim IW, Tilmes S, Lawrence DM, Vitt F, Li F.   +7 more
europepmc   +1 more source

The Pantex Lightning Mapping Array (LMA) [Slides]

None, 2021
openaire   +2 more sources

Burn Selection: How Fire Injury Shaped Human Evolution

BioEssays, Volume 48, Issue 2, February 2026.
Intentional fire use exposed humans and their ancestors to high‐temperature burn injury, a risk rare in other species, bringing major survival benefits and technologies but also repeated exposure to extreme heat. The Burn Selection Hypothesis reframes this cost of fire mastery as a unique selective pressure, which shaped our evolution.
Joshua Cuddihy, Yuemin Li, Isobel Fisher, Zoltan Takats, Dominic Friston, Declan Collins, Marcela Vizcaychipi, Matteo Fumagalli, Istvan Nagy, Armand Leroi   +9 more
wiley   +1 more source