Results 31 to 40 of about 2,974 (204)

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

The Sao Paulo Lightning Mapping Array (SPLMA): Prospects to GOES-R GLM and CHUVA [PDF]

, 2010
This paper presents the characteristics and prospects of a Lightning Mapping Array to be deployed at the city of S o Paulo (SPLMA). This LMA network will provide CHUVA campaign with total lightning, lightning channel mapping and detailed information on ...
Albrecht, Rachel I., Angelis, Carlos F., Bailey, Jeffrey C., Blakeslee, Richard J., Bruning, Eric C., Carrey, Larry, Goodman, Steven J., Koshak, William, Machado, Luiz A. T., Morales, Carlos A., Naccarato, Kleber, Pinto, Osmar, Jr., Saba, Marcelo   +12 more
core   +1 more source

Spatio-temporal dimension of lightning flashes based on three-dimensional Lightning Mapping Array [PDF]

, 2017
3D mapping system like the LMA - Lightning Mapping Array - are a leap forward in lightning observation. LMA measurements has lead to an improvement on the analysis of the fine structure of lightning, allowing to characterize the duration and maximum ...
Fabró Tàpia, Ferran, López Trujillo, Jesús Alberto, Montañá Puig, Juan, Pineda Rüegg, Nicolau, Romero Durán, David, Van der Velde, Oscar Arnoud   +5 more
core   +2 more sources

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Study on Temporal and Spatial Distribution Characteristics of Lightning on Qinghai-Xizang Plateau in Summer 2019-2023

Gaoyuan qixiang
The Qinghai-Xizang Plateau， due to its high altitude， exhibits unique lightning and convective activity compared to lower-altitude regions.Using the ‘Group’ data from the Lightning Mapping Imager （LMI） on the Fengyun-4A satellite， a statistical analysis ...
Jianghao AN, Sheng CHEN, Zeyong HU
doaj   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Atomic Scale Ordering of Liquid Water at a Dynamic Pt(111) Interface Under Electrochemical Conditions Imaged by Electron Holography

Advanced Energy Materials, EarlyView.
High resolution electron holography was used to image the projected electric potential of ordered water layers at the interface to a platinum (111) electrode. The observed reorganization of the water layers upon applying external potentials suggests that the electric potential drop of the electric double layer is mainly carried by the polarization ...
Jonas Lindner, Ulrich Ross, Tobias Meyer, Sung Sakong, Axel Gross, Michael Seibt, Christian Jooss   +6 more
wiley   +1 more source

Designing Memristive Materials for Artificial Dynamic Intelligence

Advanced Intelligent Discovery, EarlyView.
Key characteristics required of memristors for realizing next‐generation computing, along with modeling approaches employed to analyze their underlying mechanisms. These modeling techniques span from the atomic scale to the array scale and cover temporal scales ranging from picoseconds to microseconds. Hardware architectures inspired by neural networks
Youngmin Kim, Ho Won Jang
wiley   +1 more source

Three-Dimensional Lightning Characteristics Analysis over the Tibetan Plateau Based on Satellite-Based and Ground-Based Multi-Source Data

Atmosphere
Based on the data from the Chinese national ground-based (LFEDA: Low-frequency E-field Detection Array) and satellite-based lightning-detection systems (LMI: Lightning Mapping Imager), the spatial and temporal distribution statistical properties of all ...
Jie Zhu, Shulin Zhi, Dong Zheng, Zhengguo Yuan   +3 more
doaj   +1 more source

A novel framework of detecting convective initiation combining automated sampling, machine learning, and repeated model tuning from geostationary satellite data [PDF]

, 2019
This paper proposes a complete framework of a machine learning-based model that detects convective initiation (CI) from geostationary meteorological satellite data. The suggested framework consists of three main processes: (1) An automated sampling tool;
Daehyeon Han, Forkuor, Hyangsun Han, Juhyun Lee, Jungho Im, Sanggyun Lee, Seongmun Sim   +6 more
core   +2 more sources