Results 41 to 50 of about 1,439,375 (213)

Charge structure in volcanic plumes: a comparison of plume properties predicted by an integral plume model to observations of volcanic lightning during the 2010 eruption of Eyjafjallajökull, Iceland [PDF]

, 2014
Observations of volcanic lightning made using a lightning mapping array during the 2010 eruption of Eyjafjallajökull allow the trajectory and growth of the volcanic plume to be determined.
Sonja A. Behnke, Woodhouse, Mark J., Mark J. Woodhouse, Behnke, Sonja A.   +3 more
core   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Lightning-AI/lightning-bolts: Minor patch release

, 2022
What's Changed resolve require collisions by @Borda in https://github.com/Lightning-AI/lightning-bolts/pull/938 Metrics by @BaruchG in https://github.com/Lightning-AI/lightning-bolts/pull/892 Full Changelog: https://github.com/Lightning-AI/lightning ...
Ananya Harsh Jha, Shion Matsumoto, Annika Brundyn, Sidhant Sundrani, JongMok Lee, zlapp, Shivam Mehta, Jirka Borovec, Akihiro Nitta, Rohit Gupta, Teddy Koker, Clément POIRET, Jason Wang, Aditya Oke, Nathan Raw, Garry O'Donnell, Atharva Phatak, Ido Kessler, Donal Byrne, Christoph Clement, Zhengyu Yang, Baruch, Adrian Wälchli, William Falcon, Haswanth Aekula, Brian Ko, otaj   +26 more
core   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Improving prediction of short-duration heavy rainfall in Guangxi, China during the pre-summer rainy season based on Fengyun-4A lightning frequency and a machine learning algorithm

Frontiers in Earth Science
IntroductionThis study investigated the relationships between short-duration heavy rainfall (SDHR) events and lightning activity over Guangxi, China, during the pre-summer rainy season from 2019 to 2023.MethodsThe analysis was conducted using the ...
Weixiang Huang, Xiaoli Luo, Wei Zhang, Bo Feng, Xiaofei Xia, Chenying Yi, Weijun Hu   +6 more
doaj   +1 more source

Lightning-produced nitrogen oxides per flash length obtained by using TROPOMI observations and the Ebro Lightning Mapping Array [PDF]

, 2023
Lightning is one of the main sources of NOx in the Earth’s tmosphere. However, there is a large variability in NOx production during the lifetime of thunderstorms.
Seo, S., Seo, Sora, Lopez, Jesus, Erbertseder, T., Montañá Puig, Juan, Pineda, N., Loyola, Diego, Sora Seo, Gordillo Vázquez, Francisco J., Montanyá, J., Pieter Valks, Pérez-Invernón, Francisco J., Francisco J. Gordillo‐Vázquez, Oscar van derVelde, Nicolau Pineda, Valks, P., Thilo Erbertseder, Perez-Invernon, Francisco Javier, López Trujillo, J.A., van der Velde, Oscar, Pineda, Nicolau, Van der Velde, Oscar Arnoud, Francisco J. Pérez‐Invernón, Sero, Sora, Huntrieser, Heidi, Valks, Pieter, Jesús Alberto López Trujillo, Heidi Huntrieser, Diego Loyola, Huntrieser, H., Erbertseder, Thilo, Pérez Invernón, Francisco José, Gordillo Vázquez, Francisco, Pineda Rüegg, Nicolau, López Trujillo, Jesús Alberto, Joan Montanyá, Montanyá, Joan, Gordillo-Vazquez, Francisco J., Loyola, D., van der Velde, O.   +39 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

High altitude leaders mapped by the Colombia lightning mapping array [PDF]

, 2016
On April 2015 a Lightning Mapping Array network (COL-LMA) was installed at the north of Colombia. This network provides 3D mapping of the development of lightning leaders. For the first time such network has been setup in the tropics.
Van der Velde, Oscar Arnoud, Fabró Tàpia, Ferran, López Trujillo, Jesús Alberto, Montañá Puig, Juan, Romero Durán, David   +4 more
core  

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Enhanced Acoustic Adhesion Enabling Agile and Small Wall‐Climbing Robot Design With Anisotropic Origami Structure

Advanced Science, EarlyView.
This 28 g robot incorporates innovative ring structures and anisotropic origami springs to achieve high speeds and exceptional load capacity. It successfully carries a 100 g payload while ascending walls or ceilings at speeds of up to 8 and 20 cm/s, demonstrating enhanced adhesion and maneuverability over current climbing robots.
Xinxian Chen, Kanglong Yuan, Ao Qin, Yikun Liu, Yusen Ma, Jun Peng   +5 more
wiley   +1 more source