Results 81 to 90 of about 501 (172)

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

A Study Of The Electrical, Microphysical, And Kinematic Properties Of The 29 May 2012 Kingfisher Supercell [PDF]

, 2014
A supercell thunderstorm formed as part of a cluster of severe storms near Kingfisher, OK on 29 May 2012 during the Deep Convective Clouds & Chemistry (DC3) experiment.
DiGangi, Elizabeth
core  

In operando imaging of the space‐charge region in a 4H‐SiC MOSCAP using STEM‐EBIC

Journal of Microscopy, EarlyView.
Abstract In situ biasing electron microscopy is the necessary step forward in being able to characterise nanoscale devices and device interfaces. STEM‐EBIC is a new approach that can help fill the missing gaps in creating reproducible methodologies for in situ biasing TEM.
Eoin Moynihan, Arne Renz, Akif Yildirim, Peter Gammon, Richard Beanland, Ana M. Sanchez   +5 more
wiley   +1 more source

NASA SPoRT GOES-R Proving Ground Activities [PDF]

, 2010
The NASA Short-term Prediction Research and Transition (SPoRT) program is a partner with the GOES-R Proving Ground (PG) helping prepare forecasters understand the unique products to come from the GOES-R instrument suite.
Jedloec, Gary J., Fuell, Kevin K., Stano, Geoffrey T.   +2 more
core   +1 more source

Axial muscle‐fibre orientations in larval zebrafish

Journal of Anatomy, Volume 246, Issue 4, Page 517-533, April 2025.
In 4 days post‐fertilization zebrafish larvae, the fast axial muscle fibres follow helical trajectories that taper towards the tail. Adjacent muscle fibres form substantial angles relative to each other to accommodate this pattern. Using a novel semi‐automatic method, we quantified 3D fibre angles over the whole muscle volume.
Noraly M. M. E. van Meer, Johan L. van Leeuwen, Henk Schipper, Martin J. Lankheet   +3 more
wiley   +1 more source

Evaluation of the lightning imaging sensor aboard the International Space Station using Lightning Mapping Array

, 2019
In this work the data from a Lightning Mapping Array (LMA Ebro Delta) and the Lightning Imaging Sensor (ISS-LIS) has been used with the aim to explore which properties of the former make it more likely to have simultaneous ISS-LIS detections associated. To do so, the data has been divided in 10ms time bins; the ISS-LIS and LMA data points inside a same
openaire   +1 more source

Nationalist–Feminine Bifurcation: The Construction of National Morality Through Gender Regimes

Nations and Nationalism, EarlyView.
ABSTRACT This article introduces the concept of nationalist–feminine bifurcation to analyse how nationalist–populist regimes construct moral orders through gendered representations. It explores how women are simultaneously portrayed as the idealized ‘national woman’ and the excluded ‘moral threat’. Through a comparative discourse analysis of four cases—
Muhammed Ramazan Demirci
wiley   +1 more source

Identification of Critical Amino Acid Residues Required for the Polar Localization of a Rice Manganese Transporter

Plant Biotechnology Journal, EarlyView.
ABSTRACT Rice has developed an efficient system for manganese (Mn) uptake, mediated by two distinct transporters, OsNramp5 and OsMTP9. These transporters exhibit polar localization at the root exodermis and endodermis; however, the mechanisms underlying their polar localization and their role in Mn uptake remain unclear.
Noriyuki Konishi, Jian Feng Ma
wiley   +1 more source

A High‐Throughput Phenotyping Pipeline for Quinoa (Chenopodium quinoa) Panicles Using Image Analysis With Convolutional Neural Networks

Plant Breeding, EarlyView.
ABSTRACT Quinoa is a grain crop with excellent nutritional properties that has attracted global attention for its potential contribution to future food security in a changing climate. Despite its long history of cultivation, quinoa has been improved little by modern breeding and is a niche crop outside its native cultivation area.
Flavio Lozano‐Isla, Lydia Kienbaum, Bettina I. G. Haussmann, Karl Schmid   +3 more
wiley   +1 more source