Results 131 to 140 of about 3,652,623 (306)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Adjusted empirical likelihood estimation of the youden index and associated threshold for the bigamma model [PDF]
, 2009 The Youden index is a widely used measure in the framework of medical diagnostic, where the effectiveness of a biomarker (screening marker or predictor) for classifying a disease status is studied.
Molanes, Elisa M., Letón, Emilio
core +1 more source
مهندسی مخابرات جنوبThe time difference of arrival based approach to wireless localization is perhaps one of the most interesting research subjects over the past decade.
Marjan Dadkhah Tehrani +1 more
doaj
Some New Results Related to the Likelihood Ratio and the Laplace Transform Ordering
MathematicsThe purpose of this paper is twofold. First, we aim to study some new properties and relations for the likelihood ratio order. In particular, we present new integral inequalities involving the ratio of two probability density functions and the ratio of ...
Abdulaziz Alenazi
doaj +1 more source
Marginal Maximum Likelihood Estimation of Item Response Models in R [PDF]
Item response theory (IRT) models are a class of statistical models used by researchers to describe the response behaviors of individuals to a set of categorically scored items.
Matthew S. Johnson
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Radiomics based likelihood functions for cancer diagnosis. [PDF]
Sci Rep, 2019 Shakir H, Deng Y, Rasheed H, Khan TMR.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Simultaneous Testing of Mean and Variance Structures in Nonlinear Time Series Models [PDF]
This paper proposes a nonparametric simultaneous test for parametric specification of the conditional mean and variance functions in a time series regression model. The test is based on an empirical likelihood (EL) statistic that measures the goodness of
Song Xi Chen, Jiti Gao
core
Quadratic Artificial Likelihood Functions Using Estimating Functions
A vector-valued estimating function, such as the quasi-score, is typically not the gradient of any objective function. Consequently, an analogue of the likelihood function cannot be unambiguously defined by integrating the estimating function. This paper
JINFANG WANG
core +1 more source