Results 51 to 60 of about 1,552,349 (289)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Enabling the Analysis of Patient-Level Data Across Jurisdictions for Research Use: A Real-World Exploration of a Federated Likelihood Approach

International Journal of Population Data Science
Introduction The disclosure of health data is governed by strict privacy regulations which significantly restrict the transfer of data across jurisdictions.
Megan Harmon, Na Li, Tolulope Sajobi, Jessalyn Holodinsky, Tyler Williamson   +4 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Maximum Smoothed Likelihood Component Density Estimation in Mixture Models with Known Mixing Proportions [PDF]

, 2014
In this paper, we propose a maximum smoothed likelihood method to estimate the component density functions of mixture models, in which the mixing proportions are known and may differ among observations.
Li, Pengfei, Qin, Jing, Yu, Tao
core  

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Formulating likelihood functions for infectious disease dynamics for neglected tropical diseases

Frontiers in Applied Mathematics and Statistics
Reliable inference in infectious disease modeling requires careful treatment of both model structure and the relationship between latent infection dynamics and observed data.
Renata Retkute, T. Déirdre Hollingsworth, Amanda Minter   +2 more
doaj   +1 more source

Estimation of EVA Mode Choice Model Parameters with Different Types of Utility Functions

Promet (Zagreb), 2011
This paper presents the estimation of nine types of utility function parameters for the application in EVA mode choice model for the city of Ljubljana, Slovenia.
Tomaž Maher, Irena Strnad, Marijan Žura   +2 more
doaj   +1 more source

Restricted Empirical Likelihood Estimation for Time Series Autoregressive Models

Journal of Statistical Theory and Applications (JSTA), 2021
In this paper, we first illustrate the restricted empirical likelihood function, as an alternative to the usual empirical likelihood. Then, we use this quasi-empirical likelihood function as a basis for Bayesian analysis of AR(r) time series models.
Mahdieh Bayati, S.K. Ghoreishi, Jingjing Wu   +2 more
doaj   +1 more source

Constrained correlation functions from the Millennium Simulation

, 2015
Context. In previous work, we developed a quasi-Gaussian approximation for the likelihood of correlation functions, which, in contrast to the usual Gaussian approach, incorporates fundamental mathematical constraints on correlation functions.
Röseler, Randolf, Schneider, Peter, Wilking, Philipp   +2 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source