Results 71 to 80 of about 388,098 (264)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The distribution of calibrated likelihood functions on the probability-likelihood Aitchison simplex

CoRR
Preprint.
Paul-Gauthier Noé, Andreas Nautsch, Driss Matrouf, Pierre-Michel Bousquet, Jean-François Bonastre   +4 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Statistical inference of unified hybrid censoring scheme for generalized inverted exponential distribution with application to COVID-19 data

AIP Advances
Using a unified hybrid censoring scheme, this study explores statistical inferences for products with lifetimes following the generalized inverted exponential distribution. The model’s parameters are estimated using the maximum likelihood approach.
Mustafa M. Hasaballah, Yusra A. Tashkandy, Oluwafemi Samson Balogun, M. E. Bakr   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Making Likelihood Calculations Fast: Automatic Differentiation Applied to RooFit [PDF]

EPJ Web of Conferences
With the growing datasets of current and next-generation HighEnergy and Nuclear Physics (HEP/NP) experiments, statistical analysis has become more computationally demanding.
Singh Garima, Rembser Jonas, Moneta Lorenzo, Lange David, Vassilev Vassil   +4 more
doaj   +1 more source

Likelihood Ratio Tests for Monotone Functions

The Annals of Statistics, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Banerjee, Moulinath, Wellner, Jon A.
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

MLEP: an R package for exploring the maximum likelihood estimates of penetrance parameters

BMC Research Notes, 2012
Background Linkage analysis is a useful tool for detecting genetic variants that regulate a trait of interest, especially genes associated with a given disease.
Sugaya Yuki
doaj   +1 more source