Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A likelihood ratio test for stationarity of rating transitions [PDF]
For a time-continuous discrete-state Markov process as model for rating transitions, we study the time-stationarity by means of a likelihood ratio test. For multiple Markov process data from a multiplicative intensity model, maximum likelihood parameter ...
Walter, Ronja, Weißbach, Rafael
core
On the Likelihood Ratio Test of a Normal Multivariate Testing Problem II
The Annals of Mathematical Statistics, 1964 Let the random vector $X = (X_1 \cdots X_p)'$ have a multivariate normal distribution with unknown mean $\xi = (\xi_1 \cdots \xi_p)'$ and unknown nonsingular covariance matrix $\Sigma$. Write $\Sigma^{-1}\xi = \Gamma = (\Gamma_1 \cdots \Gamma_p)'$. The problem considered here is that of testing the hypothesis $H_0 : \Gamma_{q + 1} = \cdots = \Gamma_p =
openaire +4 more sources
Real-Time Detection of Incipient Inter-Turn Short Circuit and Sensor Faults in Permanent Magnet Synchronous Motor Drives Based on Generalized Likelihood Ratio Test and Structural Analysis. [PDF]
Sensors (Basel), 2022 Hasan Ebrahimi S, Choux M, Huynh VK.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A Likelihood Ratio Test of Stationarity Based on a Correlated Unobserved Components Model [PDF]
We propose a likelihood ratio (LR) test of stationarity based on a widely-used correlated unobserved components model. We verify the asymptotic distribution and consistency of the LR test, while a bootstrap version of the test is at least first-order ...
Tara M. Sinclair +2 more
core
A Novel Decoder for Unknown Diversity Channels Employing Space-Time Codes
EURASIP Journal on Advances in Signal Processing, 2002 We suggest new decoding techniques for diversity channels employing space time codes (STC) when the channel coefficients are unknown to both transmitter and receiver.
Erez Elona, Feder Meir
doaj +1 more source
A Likelihood Ratio Test for Gene-Environment Interaction Based on the Trend Effect of Genotype Under an Additive Risk Model Using the Gene-Environment Independence Assumption. [PDF]
Am J Epidemiol, 2021 de Rochemonteix M +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source